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An implantable ultrasound-powered device for the treatment of brain cancer using electromagnetic fields

Brain tumors have been proved challenging to treat. Here, we present a promising alternative by developing an implantable ultrasound-powered tumor treating device (UP-TTD) that electromagnetically disrupts the rapid division of cancer cells without any adverse effects on normal neurons, thereby safe...

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Autores principales: Yang, Yilin, Hu, Xiaoping, Liu, Yuxin, Ouyang, Bin, Zhang, Jiaxi, Jin, Huawei, Yu, Zhenhua, Liu, Ruiwei, Li, Zhe, Jiang, Lelun, Lin, Xudong, Xu, Bingzhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307245/
https://www.ncbi.nlm.nih.gov/pubmed/35867783
http://dx.doi.org/10.1126/sciadv.abm5023
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author Yang, Yilin
Hu, Xiaoping
Liu, Yuxin
Ouyang, Bin
Zhang, Jiaxi
Jin, Huawei
Yu, Zhenhua
Liu, Ruiwei
Li, Zhe
Jiang, Lelun
Lin, Xudong
Xu, Bingzhe
author_facet Yang, Yilin
Hu, Xiaoping
Liu, Yuxin
Ouyang, Bin
Zhang, Jiaxi
Jin, Huawei
Yu, Zhenhua
Liu, Ruiwei
Li, Zhe
Jiang, Lelun
Lin, Xudong
Xu, Bingzhe
author_sort Yang, Yilin
collection PubMed
description Brain tumors have been proved challenging to treat. Here, we present a promising alternative by developing an implantable ultrasound-powered tumor treating device (UP-TTD) that electromagnetically disrupts the rapid division of cancer cells without any adverse effects on normal neurons, thereby safely inhibiting brain cancer recurrence. In vitro and in vivo experiments confirmed the significant therapeutic effect of the UP-TTD, with ~58% inhibition on growth rate of clinical tumor cells and ~78% reduction of cancer area in tumor-bearing rats. This UP-TTD is wireless ultrasound-powered, chip-sized, lightweight, and easy to operate on complex surfaces, with a largely boosting therapeutic efficiency and reducing energy consumption. Meanwhile, various treatment parameters could be tuned from the UP-TTD without increasing its size or adding circuits on the integrated chip. The tuning process was simulated and discussed, showing an excellent agreement with the experimental data. The encouraging results of the UP-TTD raise the possibility of a new modality for brain cancer treatment.
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spelling pubmed-93072452022-08-09 An implantable ultrasound-powered device for the treatment of brain cancer using electromagnetic fields Yang, Yilin Hu, Xiaoping Liu, Yuxin Ouyang, Bin Zhang, Jiaxi Jin, Huawei Yu, Zhenhua Liu, Ruiwei Li, Zhe Jiang, Lelun Lin, Xudong Xu, Bingzhe Sci Adv Biomedicine and Life Sciences Brain tumors have been proved challenging to treat. Here, we present a promising alternative by developing an implantable ultrasound-powered tumor treating device (UP-TTD) that electromagnetically disrupts the rapid division of cancer cells without any adverse effects on normal neurons, thereby safely inhibiting brain cancer recurrence. In vitro and in vivo experiments confirmed the significant therapeutic effect of the UP-TTD, with ~58% inhibition on growth rate of clinical tumor cells and ~78% reduction of cancer area in tumor-bearing rats. This UP-TTD is wireless ultrasound-powered, chip-sized, lightweight, and easy to operate on complex surfaces, with a largely boosting therapeutic efficiency and reducing energy consumption. Meanwhile, various treatment parameters could be tuned from the UP-TTD without increasing its size or adding circuits on the integrated chip. The tuning process was simulated and discussed, showing an excellent agreement with the experimental data. The encouraging results of the UP-TTD raise the possibility of a new modality for brain cancer treatment. American Association for the Advancement of Science 2022-07-22 /pmc/articles/PMC9307245/ /pubmed/35867783 http://dx.doi.org/10.1126/sciadv.abm5023 Text en Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Biomedicine and Life Sciences
Yang, Yilin
Hu, Xiaoping
Liu, Yuxin
Ouyang, Bin
Zhang, Jiaxi
Jin, Huawei
Yu, Zhenhua
Liu, Ruiwei
Li, Zhe
Jiang, Lelun
Lin, Xudong
Xu, Bingzhe
An implantable ultrasound-powered device for the treatment of brain cancer using electromagnetic fields
title An implantable ultrasound-powered device for the treatment of brain cancer using electromagnetic fields
title_full An implantable ultrasound-powered device for the treatment of brain cancer using electromagnetic fields
title_fullStr An implantable ultrasound-powered device for the treatment of brain cancer using electromagnetic fields
title_full_unstemmed An implantable ultrasound-powered device for the treatment of brain cancer using electromagnetic fields
title_short An implantable ultrasound-powered device for the treatment of brain cancer using electromagnetic fields
title_sort implantable ultrasound-powered device for the treatment of brain cancer using electromagnetic fields
topic Biomedicine and Life Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307245/
https://www.ncbi.nlm.nih.gov/pubmed/35867783
http://dx.doi.org/10.1126/sciadv.abm5023
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