Ambroxol reverses tau and α-synuclein accumulation in a cholinergic N370S GBA1 mutation model

Cognitive impairment is a common non-motor complication of Parkinson’s disease (PD). Glucocerebrosidase gene (GBA1) variants are found in 10–15% of PD cases and are numerically the most important risk factor for PD and dementia with Lewy bodies. Accumulation of α-synuclein and tau pathology is thoug...

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Detalles Bibliográficos
Autores principales: Yang, Shi Yu, Taanman, Jan-Willem, Gegg, Matthew, Schapira, Anthony H V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
General Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307316/
https://www.ncbi.nlm.nih.gov/pubmed/35179198
http://dx.doi.org/10.1093/hmg/ddac038

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307316/
https://www.ncbi.nlm.nih.gov/pubmed/35179198
http://dx.doi.org/10.1093/hmg/ddac038

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