Disassembly of α6β4-mediated hemidesmosomal adhesions promotes tumorigenesis in PTEN-negative prostate cancer by targeting plectin to focal adhesions

Loss of α6β4-dependent hemidesmosomal adhesions has been observed during prostate cancer progression. However, the significance and underlying mechanisms by which aberrant hemidesmosome assembly may modulate tumorigenesis remain elusive. Using an extensive CRISPR/Cas9-mediated genetic engineering ap...

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Detalles Bibliográficos
Autores principales: Wenta, Tomasz, Schmidt, Anette, Zhang, Qin, Devarajan, Raman, Singh, Prateek, Yang, Xiayun, Ahtikoski, Anne, Vaarala, Markku, Wei, Gong-Hong, Manninen, Aki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307480/
https://www.ncbi.nlm.nih.gov/pubmed/35773413
http://dx.doi.org/10.1038/s41388-022-02389-5

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