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The metabolic stress response: Adaptation to acute-, repeated- and chronic challenges in mice
There is a strong relationship between stress and metabolism. Because acute traumatic- and chronic stress events are often accompanied with metabolic pathophysiology, it is important to understand the details of the metabolic stress response. In this study we directly compared metabolic effects of a...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307515/ https://www.ncbi.nlm.nih.gov/pubmed/35880047 http://dx.doi.org/10.1016/j.isci.2022.104693 |
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author | Kuti, Dániel Winkler, Zsuzsanna Horváth, Krisztina Juhász, Balázs Szilvásy-Szabó, Anett Fekete, Csaba Ferenczi, Szilamér Kovács, Krisztina J. |
author_facet | Kuti, Dániel Winkler, Zsuzsanna Horváth, Krisztina Juhász, Balázs Szilvásy-Szabó, Anett Fekete, Csaba Ferenczi, Szilamér Kovács, Krisztina J. |
author_sort | Kuti, Dániel |
collection | PubMed |
description | There is a strong relationship between stress and metabolism. Because acute traumatic- and chronic stress events are often accompanied with metabolic pathophysiology, it is important to understand the details of the metabolic stress response. In this study we directly compared metabolic effects of acute stress with chronic repeated- and chronic unpredictable stress in mouse models. All types of adversities increased energy expenditure, chronic stress exposure decreased body weight gain, locomotor activity and differentially affected fuel utilization. During chronic exposure to variable stressors, carbohydrates were the predominant fuels, whereas fatty acids were catabolized in acutely and repeatedly restrained animals. Chronic exposure to variable stressors in unpredictable manner provoked anxiety. Our data highlight differences in metabolic responses to acute- repeated- and chronic stressors, which might affect coping behavior and underlie stress-induced metabolic and psychopathologies. |
format | Online Article Text |
id | pubmed-9307515 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-93075152022-07-24 The metabolic stress response: Adaptation to acute-, repeated- and chronic challenges in mice Kuti, Dániel Winkler, Zsuzsanna Horváth, Krisztina Juhász, Balázs Szilvásy-Szabó, Anett Fekete, Csaba Ferenczi, Szilamér Kovács, Krisztina J. iScience Article There is a strong relationship between stress and metabolism. Because acute traumatic- and chronic stress events are often accompanied with metabolic pathophysiology, it is important to understand the details of the metabolic stress response. In this study we directly compared metabolic effects of acute stress with chronic repeated- and chronic unpredictable stress in mouse models. All types of adversities increased energy expenditure, chronic stress exposure decreased body weight gain, locomotor activity and differentially affected fuel utilization. During chronic exposure to variable stressors, carbohydrates were the predominant fuels, whereas fatty acids were catabolized in acutely and repeatedly restrained animals. Chronic exposure to variable stressors in unpredictable manner provoked anxiety. Our data highlight differences in metabolic responses to acute- repeated- and chronic stressors, which might affect coping behavior and underlie stress-induced metabolic and psychopathologies. Elsevier 2022-06-30 /pmc/articles/PMC9307515/ /pubmed/35880047 http://dx.doi.org/10.1016/j.isci.2022.104693 Text en © 2022. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Kuti, Dániel Winkler, Zsuzsanna Horváth, Krisztina Juhász, Balázs Szilvásy-Szabó, Anett Fekete, Csaba Ferenczi, Szilamér Kovács, Krisztina J. The metabolic stress response: Adaptation to acute-, repeated- and chronic challenges in mice |
title | The metabolic stress response: Adaptation to acute-, repeated- and chronic challenges in mice |
title_full | The metabolic stress response: Adaptation to acute-, repeated- and chronic challenges in mice |
title_fullStr | The metabolic stress response: Adaptation to acute-, repeated- and chronic challenges in mice |
title_full_unstemmed | The metabolic stress response: Adaptation to acute-, repeated- and chronic challenges in mice |
title_short | The metabolic stress response: Adaptation to acute-, repeated- and chronic challenges in mice |
title_sort | metabolic stress response: adaptation to acute-, repeated- and chronic challenges in mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307515/ https://www.ncbi.nlm.nih.gov/pubmed/35880047 http://dx.doi.org/10.1016/j.isci.2022.104693 |
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