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The metabolic stress response: Adaptation to acute-, repeated- and chronic challenges in mice

There is a strong relationship between stress and metabolism. Because acute traumatic- and chronic stress events are often accompanied with metabolic pathophysiology, it is important to understand the details of the metabolic stress response. In this study we directly compared metabolic effects of a...

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Autores principales: Kuti, Dániel, Winkler, Zsuzsanna, Horváth, Krisztina, Juhász, Balázs, Szilvásy-Szabó, Anett, Fekete, Csaba, Ferenczi, Szilamér, Kovács, Krisztina J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307515/
https://www.ncbi.nlm.nih.gov/pubmed/35880047
http://dx.doi.org/10.1016/j.isci.2022.104693
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author Kuti, Dániel
Winkler, Zsuzsanna
Horváth, Krisztina
Juhász, Balázs
Szilvásy-Szabó, Anett
Fekete, Csaba
Ferenczi, Szilamér
Kovács, Krisztina J.
author_facet Kuti, Dániel
Winkler, Zsuzsanna
Horváth, Krisztina
Juhász, Balázs
Szilvásy-Szabó, Anett
Fekete, Csaba
Ferenczi, Szilamér
Kovács, Krisztina J.
author_sort Kuti, Dániel
collection PubMed
description There is a strong relationship between stress and metabolism. Because acute traumatic- and chronic stress events are often accompanied with metabolic pathophysiology, it is important to understand the details of the metabolic stress response. In this study we directly compared metabolic effects of acute stress with chronic repeated- and chronic unpredictable stress in mouse models. All types of adversities increased energy expenditure, chronic stress exposure decreased body weight gain, locomotor activity and differentially affected fuel utilization. During chronic exposure to variable stressors, carbohydrates were the predominant fuels, whereas fatty acids were catabolized in acutely and repeatedly restrained animals. Chronic exposure to variable stressors in unpredictable manner provoked anxiety. Our data highlight differences in metabolic responses to acute- repeated- and chronic stressors, which might affect coping behavior and underlie stress-induced metabolic and psychopathologies.
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spelling pubmed-93075152022-07-24 The metabolic stress response: Adaptation to acute-, repeated- and chronic challenges in mice Kuti, Dániel Winkler, Zsuzsanna Horváth, Krisztina Juhász, Balázs Szilvásy-Szabó, Anett Fekete, Csaba Ferenczi, Szilamér Kovács, Krisztina J. iScience Article There is a strong relationship between stress and metabolism. Because acute traumatic- and chronic stress events are often accompanied with metabolic pathophysiology, it is important to understand the details of the metabolic stress response. In this study we directly compared metabolic effects of acute stress with chronic repeated- and chronic unpredictable stress in mouse models. All types of adversities increased energy expenditure, chronic stress exposure decreased body weight gain, locomotor activity and differentially affected fuel utilization. During chronic exposure to variable stressors, carbohydrates were the predominant fuels, whereas fatty acids were catabolized in acutely and repeatedly restrained animals. Chronic exposure to variable stressors in unpredictable manner provoked anxiety. Our data highlight differences in metabolic responses to acute- repeated- and chronic stressors, which might affect coping behavior and underlie stress-induced metabolic and psychopathologies. Elsevier 2022-06-30 /pmc/articles/PMC9307515/ /pubmed/35880047 http://dx.doi.org/10.1016/j.isci.2022.104693 Text en © 2022. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Kuti, Dániel
Winkler, Zsuzsanna
Horváth, Krisztina
Juhász, Balázs
Szilvásy-Szabó, Anett
Fekete, Csaba
Ferenczi, Szilamér
Kovács, Krisztina J.
The metabolic stress response: Adaptation to acute-, repeated- and chronic challenges in mice
title The metabolic stress response: Adaptation to acute-, repeated- and chronic challenges in mice
title_full The metabolic stress response: Adaptation to acute-, repeated- and chronic challenges in mice
title_fullStr The metabolic stress response: Adaptation to acute-, repeated- and chronic challenges in mice
title_full_unstemmed The metabolic stress response: Adaptation to acute-, repeated- and chronic challenges in mice
title_short The metabolic stress response: Adaptation to acute-, repeated- and chronic challenges in mice
title_sort metabolic stress response: adaptation to acute-, repeated- and chronic challenges in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307515/
https://www.ncbi.nlm.nih.gov/pubmed/35880047
http://dx.doi.org/10.1016/j.isci.2022.104693
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