A critical role of the mechanosensor PIEZO1 in glucose-induced insulin secretion in pancreatic β-cells

Glucose-induced insulin secretion depends on β-cell electrical activity. Inhibition of ATP-regulated potassium (K(ATP)) channels is a key event in this process. However, K(ATP) channel closure alone is not sufficient to induce β-cell electrical activity; activation of a depolarizing membrane current...

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Detalles Bibliográficos
Autores principales: Ye, Yingying, Barghouth, Mohammad, Dou, Haiqiang, Luan, Cheng, Wang, Yongzhi, Karagiannopoulos, Alexandros, Jiang, Xiaoping, Krus, Ulrika, Fex, Malin, Zhang, Quan, Eliasson, Lena, Rorsman, Patrik, Zhang, Enming, Renström, Erik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307633/
https://www.ncbi.nlm.nih.gov/pubmed/35869052
http://dx.doi.org/10.1038/s41467-022-31103-y

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