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TDP1-independent pathways in the process and repair of TOP1-induced DNA damage

Anticancer drugs, such as camptothecin (CPT), trap topoisomerase I (TOP1) on DNA and form TOP1 cleavage complexes (TOP1cc). Alternative repair pathways have been suggested in the repair of TOP1cc. However, how these pathways work with TDP1, a key repair enzyme that specifically hydrolyze the covalen...

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Detalles Bibliográficos
Autores principales:	Zhang, Huimin, Xiong, Yun, Su, Dan, Wang, Chao, Srivastava, Mrinal, Tang, Mengfan, Feng, Xu, Huang, Min, Chen, Zhen, Chen, Junjie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307636/ https://www.ncbi.nlm.nih.gov/pubmed/35869071 http://dx.doi.org/10.1038/s41467-022-31801-7

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