Robust osteogenic efficacy of 2α-heteroarylalkyl vitamin D analogue AH-1 in VDR (R270L) hereditary vitamin D-dependent rickets model rats

Active vitamin D form 1α,25-dihydroxtvitamin D(3) (1,25(OH)(2)D(3)) plays pivotal roles in calcium homeostasis and osteogenesis via its transcription regulation effect via binding to vitamin D receptor (VDR). Mutated VDR often causes hereditary vitamin D-dependent rickets (VDDR) type II, and patient...

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Detalles Bibliográficos
Autores principales: Nishikawa, Miyu, Murose, Naruhiro, Mano, Hiroki, Yasuda, Kaori, Isogai, Yasuhiro, Kittaka, Atsushi, Takano, Masashi, Ikushiro, Shinichi, Sakaki, Toshiyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307643/
https://www.ncbi.nlm.nih.gov/pubmed/35869242
http://dx.doi.org/10.1038/s41598-022-16819-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307643/
https://www.ncbi.nlm.nih.gov/pubmed/35869242
http://dx.doi.org/10.1038/s41598-022-16819-7

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