An electrochemical gram-scale protocol for pyridylation of inert N-heterocycles with cyanopyridines

Here, we present a protocol to decyanopyridate inert N-heterocycles access to N-fused heterocycles via the mechanism of dual proton-coupled electron transfer (PCET). We describe a detailed guide to performing an electrochemical gram-scale protocol for decyanopyridation of inert N-heterocycles. The d...

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Detalles Bibliográficos
Autores principales: Niu, Cong, Yang, Jianjing, Yan, Kelu, Xie, Jiafang, Jiang, Wei, Li, Bingwen, Wen, Jiangwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307674/
https://www.ncbi.nlm.nih.gov/pubmed/35880134
http://dx.doi.org/10.1016/j.xpro.2022.101565
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author Niu, Cong
Yang, Jianjing
Yan, Kelu
Xie, Jiafang
Jiang, Wei
Li, Bingwen
Wen, Jiangwei
author_facet Niu, Cong
Yang, Jianjing
Yan, Kelu
Xie, Jiafang
Jiang, Wei
Li, Bingwen
Wen, Jiangwei
author_sort Niu, Cong
collection PubMed
description Here, we present a protocol to decyanopyridate inert N-heterocycles access to N-fused heterocycles via the mechanism of dual proton-coupled electron transfer (PCET). We describe a detailed guide to performing an electrochemical gram-scale protocol for decyanopyridation of inert N-heterocycles. The desired pyridylated quinolone is synthesized in a 5.0 mmol scale with a yield of 76%. The protocol is limited to cyanopyridines. For complete details on the use and execution of this protocol, please refer to Niu et al. (2022).
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spelling pubmed-93076742022-07-24 An electrochemical gram-scale protocol for pyridylation of inert N-heterocycles with cyanopyridines Niu, Cong Yang, Jianjing Yan, Kelu Xie, Jiafang Jiang, Wei Li, Bingwen Wen, Jiangwei STAR Protoc Protocol Here, we present a protocol to decyanopyridate inert N-heterocycles access to N-fused heterocycles via the mechanism of dual proton-coupled electron transfer (PCET). We describe a detailed guide to performing an electrochemical gram-scale protocol for decyanopyridation of inert N-heterocycles. The desired pyridylated quinolone is synthesized in a 5.0 mmol scale with a yield of 76%. The protocol is limited to cyanopyridines. For complete details on the use and execution of this protocol, please refer to Niu et al. (2022). Elsevier 2022-07-19 /pmc/articles/PMC9307674/ /pubmed/35880134 http://dx.doi.org/10.1016/j.xpro.2022.101565 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Protocol
Niu, Cong
Yang, Jianjing
Yan, Kelu
Xie, Jiafang
Jiang, Wei
Li, Bingwen
Wen, Jiangwei
An electrochemical gram-scale protocol for pyridylation of inert N-heterocycles with cyanopyridines
title An electrochemical gram-scale protocol for pyridylation of inert N-heterocycles with cyanopyridines
title_full An electrochemical gram-scale protocol for pyridylation of inert N-heterocycles with cyanopyridines
title_fullStr An electrochemical gram-scale protocol for pyridylation of inert N-heterocycles with cyanopyridines
title_full_unstemmed An electrochemical gram-scale protocol for pyridylation of inert N-heterocycles with cyanopyridines
title_short An electrochemical gram-scale protocol for pyridylation of inert N-heterocycles with cyanopyridines
title_sort electrochemical gram-scale protocol for pyridylation of inert n-heterocycles with cyanopyridines
topic Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307674/
https://www.ncbi.nlm.nih.gov/pubmed/35880134
http://dx.doi.org/10.1016/j.xpro.2022.101565
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