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Heparin induces α-synuclein to form new fibril polymorphs with attenuated neuropathology

α-Synuclein (α-syn), as a primary pathogenic protein in Parkinson’s disease (PD) and other synucleinopathies, exhibits a high potential to form polymorphic fibrils. Chemical ligands have been found to involve in the assembly of α-syn fibrils in patients’ brains. However, how ligands influence the fi...

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Detalles Bibliográficos
Autores principales:	Tao, Youqi, Sun, Yunpeng, Lv, Shiran, Xia, Wencheng, Zhao, Kun, Xu, Qianhui, Zhao, Qinyue, He, Lin, Le, Weidong, Wang, Yong, Liu, Cong, Li, Dan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307803/ https://www.ncbi.nlm.nih.gov/pubmed/35869048 http://dx.doi.org/10.1038/s41467-022-31790-7

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