mTOR contributes to endothelium-dependent vasorelaxation by promoting eNOS expression and preventing eNOS uncoupling

Clinically used inhibitors of mammalian target of rapamycin (mTOR) negatively impacts endothelial-dependent vasodilatation (EDD) through unidentified mechanisms. Here we show that either the endothelium-specific deletion of Mtor to inhibit both mTOR complexes, or depletion of Raptor or Rictor to dis...

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Detalles Bibliográficos
Autores principales: Wang, Yiying, Li, Qiannan, Zhang, Zhiyang, Peng, Kai, Zhang, Dai-Min, Yang, Qianlu, Passerini, Anthony G., Simon, Scott I., Sun, ChongXiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307829/
https://www.ncbi.nlm.nih.gov/pubmed/35869262
http://dx.doi.org/10.1038/s42003-022-03653-w

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