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Structure of DNMT3B homo-oligomer reveals vulnerability to impairment by ICF mutations

DNA methyltransferase DNMT3B plays an essential role in establishment of DNA methylation during embryogenesis. Mutations of DNMT3B are associated with human diseases, notably the immunodeficiency, centromeric instability and facial anomalies (ICF) syndrome. How ICF mutations affect DNMT3B activity i...

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Detalles Bibliográficos
Autores principales:	Gao, Linfeng, Guo, Yiran, Biswal, Mahamaya, Lu, Jiuwei, Yin, Jiekai, Fang, Jian, Chen, Xinyi, Shao, Zengyu, Huang, Mengjiang, Wang, Yinsheng, Wang, Gang Greg, Song, Jikui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307851/ https://www.ncbi.nlm.nih.gov/pubmed/35869095 http://dx.doi.org/10.1038/s41467-022-31933-w

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