Mesenchymal/stromal stem cells: necessary factors in tumour progression

Mesenchymal/stromal stem cells (MSCs) are a crucial component of the tumour microenvironment (TME). They can be recruited from normal tissues into the TME and educated by tumour cells to transform into tumour-associated MSCs, which are oncogenic cells that promote tumour development and progression...

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Detalles Bibliográficos
Autores principales: Li, Xinyu, Fan, Qing, Peng, Xueqiang, Yang, Shuo, Wei, Shibo, Liu, Jingang, Yang, Liang, Li, Hangyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307857/
https://www.ncbi.nlm.nih.gov/pubmed/35869057
http://dx.doi.org/10.1038/s41420-022-01107-0
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author Li, Xinyu
Fan, Qing
Peng, Xueqiang
Yang, Shuo
Wei, Shibo
Liu, Jingang
Yang, Liang
Li, Hangyu
author_facet Li, Xinyu
Fan, Qing
Peng, Xueqiang
Yang, Shuo
Wei, Shibo
Liu, Jingang
Yang, Liang
Li, Hangyu
author_sort Li, Xinyu
collection PubMed
description Mesenchymal/stromal stem cells (MSCs) are a crucial component of the tumour microenvironment (TME). They can be recruited from normal tissues into the TME and educated by tumour cells to transform into tumour-associated MSCs, which are oncogenic cells that promote tumour development and progression by impacting or transforming into various kinds of cells, such as immune cells and endothelial cells. Targeting MSCs in the TME is a novel strategy to prevent malignant processes. Exosomes, as communicators, carry various RNAs and proteins and thus link MSCs and the TME, which provides options for improving outcomes and developing targeted treatment.
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spelling pubmed-93078572022-07-24 Mesenchymal/stromal stem cells: necessary factors in tumour progression Li, Xinyu Fan, Qing Peng, Xueqiang Yang, Shuo Wei, Shibo Liu, Jingang Yang, Liang Li, Hangyu Cell Death Discov Review Article Mesenchymal/stromal stem cells (MSCs) are a crucial component of the tumour microenvironment (TME). They can be recruited from normal tissues into the TME and educated by tumour cells to transform into tumour-associated MSCs, which are oncogenic cells that promote tumour development and progression by impacting or transforming into various kinds of cells, such as immune cells and endothelial cells. Targeting MSCs in the TME is a novel strategy to prevent malignant processes. Exosomes, as communicators, carry various RNAs and proteins and thus link MSCs and the TME, which provides options for improving outcomes and developing targeted treatment. Nature Publishing Group UK 2022-07-22 /pmc/articles/PMC9307857/ /pubmed/35869057 http://dx.doi.org/10.1038/s41420-022-01107-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Li, Xinyu
Fan, Qing
Peng, Xueqiang
Yang, Shuo
Wei, Shibo
Liu, Jingang
Yang, Liang
Li, Hangyu
Mesenchymal/stromal stem cells: necessary factors in tumour progression
title Mesenchymal/stromal stem cells: necessary factors in tumour progression
title_full Mesenchymal/stromal stem cells: necessary factors in tumour progression
title_fullStr Mesenchymal/stromal stem cells: necessary factors in tumour progression
title_full_unstemmed Mesenchymal/stromal stem cells: necessary factors in tumour progression
title_short Mesenchymal/stromal stem cells: necessary factors in tumour progression
title_sort mesenchymal/stromal stem cells: necessary factors in tumour progression
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307857/
https://www.ncbi.nlm.nih.gov/pubmed/35869057
http://dx.doi.org/10.1038/s41420-022-01107-0
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