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Seed-competent tau monomer initiates pathology in a tauopathy mouse model

Tau aggregation into ordered assemblies causes neurodegenerative tauopathies. We previously reported that tau monomer exists in either inert (M(i)) or seed-competent (M(s)) conformational ensembles and that M(s) encodes strains, that is, unique, self-replicating, biologically active assemblies. It i...

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Detalles Bibliográficos
Autores principales:	Mirbaha, Hilda, Chen, Dailu, Mullapudi, Vishruth, Terpack, Sandi Jo, White, Charles L., Joachimiak, Lukasz A., Diamond, Marc I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307951/ https://www.ncbi.nlm.nih.gov/pubmed/35750209 http://dx.doi.org/10.1016/j.jbc.2022.102163

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