Simultaneous presentation of idiopathic uveitis in monozygotic 4-year-old twin boys

PURPOSE: To report monozygotic twin 4-year-old boys with chronic bilateral anterior uveitis with simultaneous onset. OBSERVATIONS: Here we report monozygotic twin 4-year-old boys with chronic bilateral anterior uveitis. The boys had simultaneous onset of uveitis and identical features. Evaluation, i...

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Detalles Bibliográficos
Autores principales: Baxter, Sarah, Van Gelder, Russell N., Cheung, Jason C., Basiaga, Matthew L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307958/
https://www.ncbi.nlm.nih.gov/pubmed/35880208
http://dx.doi.org/10.1016/j.ajoc.2022.101666
Descripción
Sumario:PURPOSE: To report monozygotic twin 4-year-old boys with chronic bilateral anterior uveitis with simultaneous onset. OBSERVATIONS: Here we report monozygotic twin 4-year-old boys with chronic bilateral anterior uveitis. The boys had simultaneous onset of uveitis and identical features. Evaluation, including whole exome sequencing (WES), failed to reveal a specific causative etiology. Each patient responded well to immune modulation and achieved uveitis remission on methotrexate monotherapy off topical glucocorticoids. CONCLUSIONS AND IMPORTANCE: From this case of monozygotic twin boys presenting with chronic uveitis, we conclude that monozygotic twins may warrant evaluation in the setting of idiopathic uveitis, especially in young patients unable to express an adequate history.

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