Favipiravir and Its Structural Analogs: Antiviral Activity and Synthesis Methods

1,4-Pyrazine-3-carboxamide-based antiviral compounds have been under intensive study for the last 20 years. One of these compounds, favipiravir (6-fluoro-3-hydroxypyrazine-2-carboxamide, T-705), is approved for use against the influenza infection in a number of countries. Now, favipiravir is being a...

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Detalles Bibliográficos
Autores principales: Konstantinova, I. D., L.Andronova, V., Fateev, I. V., Esipov, R. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307979/
https://www.ncbi.nlm.nih.gov/pubmed/35923566
http://dx.doi.org/10.32607/actanaturae.11652
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author Konstantinova, I. D.
L.Andronova, V.
Fateev, I. V.
Esipov, R. S.
author_facet Konstantinova, I. D.
L.Andronova, V.
Fateev, I. V.
Esipov, R. S.
author_sort Konstantinova, I. D.
collection PubMed
description 1,4-Pyrazine-3-carboxamide-based antiviral compounds have been under intensive study for the last 20 years. One of these compounds, favipiravir (6-fluoro-3-hydroxypyrazine-2-carboxamide, T-705), is approved for use against the influenza infection in a number of countries. Now, favipiravir is being actively used against COVID-19. This review describes the in vivo metabolism of favipiravir, the mechanism of its antiviral activity, clinical findings, toxic properties, and the chemical synthesis routes for its production. We provide data on the synthesis and antiviral activity of structural analogs of favipiravir, including nucleosides and nucleotides based on them.
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spelling pubmed-93079792022-08-02 Favipiravir and Its Structural Analogs: Antiviral Activity and Synthesis Methods Konstantinova, I. D. L.Andronova, V. Fateev, I. V. Esipov, R. S. Acta Naturae Research Article 1,4-Pyrazine-3-carboxamide-based antiviral compounds have been under intensive study for the last 20 years. One of these compounds, favipiravir (6-fluoro-3-hydroxypyrazine-2-carboxamide, T-705), is approved for use against the influenza infection in a number of countries. Now, favipiravir is being actively used against COVID-19. This review describes the in vivo metabolism of favipiravir, the mechanism of its antiviral activity, clinical findings, toxic properties, and the chemical synthesis routes for its production. We provide data on the synthesis and antiviral activity of structural analogs of favipiravir, including nucleosides and nucleotides based on them. A.I. Gordeyev 2022 /pmc/articles/PMC9307979/ /pubmed/35923566 http://dx.doi.org/10.32607/actanaturae.11652 Text en Copyright ® 2022 National Research University Higher School of Economics. https://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Konstantinova, I. D.
L.Andronova, V.
Fateev, I. V.
Esipov, R. S.
Favipiravir and Its Structural Analogs: Antiviral Activity and Synthesis Methods
title Favipiravir and Its Structural Analogs: Antiviral Activity and Synthesis Methods
title_full Favipiravir and Its Structural Analogs: Antiviral Activity and Synthesis Methods
title_fullStr Favipiravir and Its Structural Analogs: Antiviral Activity and Synthesis Methods
title_full_unstemmed Favipiravir and Its Structural Analogs: Antiviral Activity and Synthesis Methods
title_short Favipiravir and Its Structural Analogs: Antiviral Activity and Synthesis Methods
title_sort favipiravir and its structural analogs: antiviral activity and synthesis methods
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307979/
https://www.ncbi.nlm.nih.gov/pubmed/35923566
http://dx.doi.org/10.32607/actanaturae.11652
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AT fateeviv favipiraviranditsstructuralanalogsantiviralactivityandsynthesismethods
AT esipovrs favipiraviranditsstructuralanalogsantiviralactivityandsynthesismethods

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