Imidazole Derivative As a Novel Translation Inhibitor

Searching for novel compounds with antibiotic activity and understanding their mechanism of action is extremely important. The ribosome is one of the main targets for antibiotics in bacterial cells. Even if the molecule does not suit the clinical application for whatever reasons, an investigation of...

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Autores principales: Lukianov, D. A., Buev, V. S., Ivanenkov, Y. A., Kartsev, V. G., Skvortsov, D. A., Osterman, I. A., Sergiev, P. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307981/
https://www.ncbi.nlm.nih.gov/pubmed/35923569
http://dx.doi.org/10.32607/actanaturae.11654
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author Lukianov, D. A.
Buev, V. S.
Ivanenkov, Y. A.
Kartsev, V. G.
Skvortsov, D. A.
Osterman, I. A.
Sergiev, P. V.
author_facet Lukianov, D. A.
Buev, V. S.
Ivanenkov, Y. A.
Kartsev, V. G.
Skvortsov, D. A.
Osterman, I. A.
Sergiev, P. V.
author_sort Lukianov, D. A.
collection PubMed
description Searching for novel compounds with antibiotic activity and understanding their mechanism of action is extremely important. The ribosome is one of the main targets for antibiotics in bacterial cells. Even if the molecule does not suit the clinical application for whatever reasons, an investigation of its mechanism of action can deepen our understanding of the ribosome function. Such data can inform us on how the already used translational inhibitors can be modified. In this study, we demonstrate that 1-(2-oxo-2-((4-phenoxyphenyl)
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spelling pubmed-93079812022-08-02 Imidazole Derivative As a Novel Translation Inhibitor Lukianov, D. A. Buev, V. S. Ivanenkov, Y. A. Kartsev, V. G. Skvortsov, D. A. Osterman, I. A. Sergiev, P. V. Acta Naturae Research Article Searching for novel compounds with antibiotic activity and understanding their mechanism of action is extremely important. The ribosome is one of the main targets for antibiotics in bacterial cells. Even if the molecule does not suit the clinical application for whatever reasons, an investigation of its mechanism of action can deepen our understanding of the ribosome function. Such data can inform us on how the already used translational inhibitors can be modified. In this study, we demonstrate that 1-(2-oxo-2-((4-phenoxyphenyl) A.I. Gordeyev 2022 /pmc/articles/PMC9307981/ /pubmed/35923569 http://dx.doi.org/10.32607/actanaturae.11654 Text en Copyright ® 2022 National Research University Higher School of Economics. https://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Lukianov, D. A.
Buev, V. S.
Ivanenkov, Y. A.
Kartsev, V. G.
Skvortsov, D. A.
Osterman, I. A.
Sergiev, P. V.
Imidazole Derivative As a Novel Translation Inhibitor
title Imidazole Derivative As a Novel Translation Inhibitor
title_full Imidazole Derivative As a Novel Translation Inhibitor
title_fullStr Imidazole Derivative As a Novel Translation Inhibitor
title_full_unstemmed Imidazole Derivative As a Novel Translation Inhibitor
title_short Imidazole Derivative As a Novel Translation Inhibitor
title_sort imidazole derivative as a novel translation inhibitor
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307981/
https://www.ncbi.nlm.nih.gov/pubmed/35923569
http://dx.doi.org/10.32607/actanaturae.11654
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