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Impact of Sevoflurane and Thiopental Used Over the Course of Electroconvulsive Therapy: Propensity Score Matching Analysis

OBJECTIVE: Although anesthetics play an important role in electroconvulsive therapy (ECT), the clinical efficacy and seizure adequacy of sevoflurane in the course of ECT remain unclear. The purpose of this study was to examine the clinical efficacy and seizure adequacy of sevoflurane, compared with...

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Autores principales: Yatomi, Taisuke, Uchida, Takahito, Takamiya, Akihiro, Wada, Masataka, Kudo, Shun, Nakajima, Kazuki, Nishida, Hana, Yamagata, Bun, Mimura, Masaru, Hirano, Jinichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9308003/
https://www.ncbi.nlm.nih.gov/pubmed/35880104
http://dx.doi.org/10.3389/fnhum.2022.933622
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author Yatomi, Taisuke
Uchida, Takahito
Takamiya, Akihiro
Wada, Masataka
Kudo, Shun
Nakajima, Kazuki
Nishida, Hana
Yamagata, Bun
Mimura, Masaru
Hirano, Jinichi
author_facet Yatomi, Taisuke
Uchida, Takahito
Takamiya, Akihiro
Wada, Masataka
Kudo, Shun
Nakajima, Kazuki
Nishida, Hana
Yamagata, Bun
Mimura, Masaru
Hirano, Jinichi
author_sort Yatomi, Taisuke
collection PubMed
description OBJECTIVE: Although anesthetics play an important role in electroconvulsive therapy (ECT), the clinical efficacy and seizure adequacy of sevoflurane in the course of ECT remain unclear. The purpose of this study was to examine the clinical efficacy and seizure adequacy of sevoflurane, compared with those of thiopental, in the course of ECT in patients with mood disorders. METHODS: We conducted a retrospective chart review. Patients who underwent a course of ECT and received sevoflurane (n = 26) or thiopental (n = 26) were included. Factors associated with ECT and treatment outcomes were compared between the two groups using propensity score (PS) matching. Between-group differences were examined using an independent t-test for continuous variables and a χ(2)-test for categorical variables. RESULTS: Patients who received sevoflurane needed more stimulations (sevoflurane: 13.2 ± 4 times, thiopental: 10.0 ± 2.5 times, df = 51, p = 0.001) and sessions (sevoflurane: 10.0 ± 2.1 times, thiopental: 8.4 ± 2.1 times, df = 51, p = 0.01) and had more inadequate seizures (sevoflurane: 5 ± 3.9 times, thiopental: 2.7 ± 2.7 times, df = 51, p = 0.015). Remission and response rates were similar in both groups. CONCLUSION: The present findings indicate that sevoflurane should be used with caution in ECT and only when the clinical rationale is clear.
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spelling pubmed-93080032022-07-24 Impact of Sevoflurane and Thiopental Used Over the Course of Electroconvulsive Therapy: Propensity Score Matching Analysis Yatomi, Taisuke Uchida, Takahito Takamiya, Akihiro Wada, Masataka Kudo, Shun Nakajima, Kazuki Nishida, Hana Yamagata, Bun Mimura, Masaru Hirano, Jinichi Front Hum Neurosci Neuroscience OBJECTIVE: Although anesthetics play an important role in electroconvulsive therapy (ECT), the clinical efficacy and seizure adequacy of sevoflurane in the course of ECT remain unclear. The purpose of this study was to examine the clinical efficacy and seizure adequacy of sevoflurane, compared with those of thiopental, in the course of ECT in patients with mood disorders. METHODS: We conducted a retrospective chart review. Patients who underwent a course of ECT and received sevoflurane (n = 26) or thiopental (n = 26) were included. Factors associated with ECT and treatment outcomes were compared between the two groups using propensity score (PS) matching. Between-group differences were examined using an independent t-test for continuous variables and a χ(2)-test for categorical variables. RESULTS: Patients who received sevoflurane needed more stimulations (sevoflurane: 13.2 ± 4 times, thiopental: 10.0 ± 2.5 times, df = 51, p = 0.001) and sessions (sevoflurane: 10.0 ± 2.1 times, thiopental: 8.4 ± 2.1 times, df = 51, p = 0.01) and had more inadequate seizures (sevoflurane: 5 ± 3.9 times, thiopental: 2.7 ± 2.7 times, df = 51, p = 0.015). Remission and response rates were similar in both groups. CONCLUSION: The present findings indicate that sevoflurane should be used with caution in ECT and only when the clinical rationale is clear. Frontiers Media S.A. 2022-07-08 /pmc/articles/PMC9308003/ /pubmed/35880104 http://dx.doi.org/10.3389/fnhum.2022.933622 Text en Copyright © 2022 Yatomi, Uchida, Takamiya, Wada, Kudo, Nakajima, Nishida, Yamagata, Mimura and Hirano. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Yatomi, Taisuke
Uchida, Takahito
Takamiya, Akihiro
Wada, Masataka
Kudo, Shun
Nakajima, Kazuki
Nishida, Hana
Yamagata, Bun
Mimura, Masaru
Hirano, Jinichi
Impact of Sevoflurane and Thiopental Used Over the Course of Electroconvulsive Therapy: Propensity Score Matching Analysis
title Impact of Sevoflurane and Thiopental Used Over the Course of Electroconvulsive Therapy: Propensity Score Matching Analysis
title_full Impact of Sevoflurane and Thiopental Used Over the Course of Electroconvulsive Therapy: Propensity Score Matching Analysis
title_fullStr Impact of Sevoflurane and Thiopental Used Over the Course of Electroconvulsive Therapy: Propensity Score Matching Analysis
title_full_unstemmed Impact of Sevoflurane and Thiopental Used Over the Course of Electroconvulsive Therapy: Propensity Score Matching Analysis
title_short Impact of Sevoflurane and Thiopental Used Over the Course of Electroconvulsive Therapy: Propensity Score Matching Analysis
title_sort impact of sevoflurane and thiopental used over the course of electroconvulsive therapy: propensity score matching analysis
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9308003/
https://www.ncbi.nlm.nih.gov/pubmed/35880104
http://dx.doi.org/10.3389/fnhum.2022.933622
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