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Progranulin Preserves Autophagy Flux and Mitochondrial Function in Rat Cortical Neurons Under High Glucose Stress

Chronic hyperglycemia in type II diabetes results in impaired autophagy function, accumulation of protein aggregates, and neurodegeneration. However, little is known about how to preserve autophagy function under hyperglycemic conditions. In this study, we tested whether progranulin (PGRN), a neurot...

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Detalles Bibliográficos
Autores principales:	Dedert, Cass, Mishra, Vandana, Aggarwal, Geetika, Nguyen, Andrew D., Xu, Fenglian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9308004/ https://www.ncbi.nlm.nih.gov/pubmed/35880011 http://dx.doi.org/10.3389/fncel.2022.874258

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