Induction of iPSC-derived Prg4-positive cells with characteristics of superficial zone chondrocytes and fibroblast-like synovial cells

BACKGROUND: Lubricin, a proteoglycan encoded by the PRG4 gene, is synthesised by superficial zone (SFZ) chondrocytes and synovial cells. It reduces friction between joints and allows smooth sliding of tendons. Although lubricin has been shown to be effective against osteoarthritis and synovitis in a...

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Detalles Bibliográficos
Autores principales: Satake, Takashi, Komura, Shingo, Aoki, Hitomi, Hirakawa, Akihiro, Imai, Yuuki, Akiyama, Haruhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9308249/
https://www.ncbi.nlm.nih.gov/pubmed/35870887
http://dx.doi.org/10.1186/s12860-022-00431-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9308249/
https://www.ncbi.nlm.nih.gov/pubmed/35870887
http://dx.doi.org/10.1186/s12860-022-00431-8

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