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A potent tumor-selective ERK pathway inactivator with high therapeutic index

FDA-approved BRAF and MEK small molecule inhibitors have demonstrated some level of efficacy in patients with metastatic melanomas. However, these “targeted” therapeutics have a very low therapeutic index, since these agents affect normal cells, causing undesirable, even fatal, side effects. To addr...

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Detalles Bibliográficos
Autores principales:	Zuo, Zehua, Liu, Jie, Sun, Zhihao, Silverstein, Rachel, Zou, Meijuan, Finkel, Toren, Bugge, Thomas H, Leppla, Stephen H, Liu, Shihui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Biological, Health, and Medical Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9308561/ https://www.ncbi.nlm.nih.gov/pubmed/35899070 http://dx.doi.org/10.1093/pnasnexus/pgac104

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