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[(68) Ga]Ga-FAPI uptake correlates with the state of chronic kidney disease

PURPOSE: Kidney fibrosis leads to a progressive reduction in kidney function ultimately resulting in kidney failure. Diagnostic tools to detect kidney fibrosis are all invasive in nature requiring kidney biopsies with subsequent histological validation. In this retrospective study, the diagnostic va...

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Autores principales: Conen, Patrick, Pennetta, Francesca, Dendl, Katharina, Hertel, Fabian, Vogg, Andreas, Haberkorn, Uwe, Giesel, Frederik L., Mottaghy, Felix M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9308582/
https://www.ncbi.nlm.nih.gov/pubmed/34988624
http://dx.doi.org/10.1007/s00259-021-05660-1
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author Conen, Patrick
Pennetta, Francesca
Dendl, Katharina
Hertel, Fabian
Vogg, Andreas
Haberkorn, Uwe
Giesel, Frederik L.
Mottaghy, Felix M.
author_facet Conen, Patrick
Pennetta, Francesca
Dendl, Katharina
Hertel, Fabian
Vogg, Andreas
Haberkorn, Uwe
Giesel, Frederik L.
Mottaghy, Felix M.
author_sort Conen, Patrick
collection PubMed
description PURPOSE: Kidney fibrosis leads to a progressive reduction in kidney function ultimately resulting in kidney failure. Diagnostic tools to detect kidney fibrosis are all invasive in nature requiring kidney biopsies with subsequent histological validation. In this retrospective study, the diagnostic value of three different radiotracers for the noninvasive prediction of kidney fibrosis was analyzed, taking into account the glomerular filtration rate (GFR) and the intra-renal parenchymal radiotracer uptake. METHODS: In 81 patients receiving either one of the following molecular imaging probes, [(68) Ga]Ga-FAPI, [(68) Ga]Ga-PSMA, or [(68) Ga]Ga-DOTATOC, kidney function parameters were correlated with SUVmax and SUVmean of the renal parenchyma and background activity measured in lung parenchyma, myocardium, gluteal muscle, and the abdominal aorta. Patients were clustered according to their grade of chronic kidney disease (CKD), and a regression analysis and one-way ANOVA were conducted in this retrospective analysis. RESULTS: We found a negative correlation between GFR and [(68) Ga]Ga-FAPI uptake for both SUVmax and SUVmean values, whereas background activity showed no correlation with GFR. [(68) Ga]Ga-DOTATOC and [(68) Ga]Ga-PSMA did not correlate between CKD stage and intra-renal parenchymal radiotracer uptake. Only [(68) Ga]Ga-PSMA background activity exhibited a positive correlation with GFR suggesting an unspecific binding/retention potentially due to longer circulation times. CONCLUSION: There is a significant negative correlation between renal parenchymal [(68) Ga]Ga-FAPI uptake and GFR, which was not the case for [(68) Ga]Ga-DOTATOC and [(68) Ga]Ga-PSMA. This correlation suggests a specific binding of FAPI rather than a potential unspecific retention in the renal parenchyma, underlining the potential value of [(68) Ga]Ga-FAPI for the noninvasive quantitative evaluation of kidney fibrosis.
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spelling pubmed-93085822022-07-25 [(68) Ga]Ga-FAPI uptake correlates with the state of chronic kidney disease Conen, Patrick Pennetta, Francesca Dendl, Katharina Hertel, Fabian Vogg, Andreas Haberkorn, Uwe Giesel, Frederik L. Mottaghy, Felix M. Eur J Nucl Med Mol Imaging Original Article PURPOSE: Kidney fibrosis leads to a progressive reduction in kidney function ultimately resulting in kidney failure. Diagnostic tools to detect kidney fibrosis are all invasive in nature requiring kidney biopsies with subsequent histological validation. In this retrospective study, the diagnostic value of three different radiotracers for the noninvasive prediction of kidney fibrosis was analyzed, taking into account the glomerular filtration rate (GFR) and the intra-renal parenchymal radiotracer uptake. METHODS: In 81 patients receiving either one of the following molecular imaging probes, [(68) Ga]Ga-FAPI, [(68) Ga]Ga-PSMA, or [(68) Ga]Ga-DOTATOC, kidney function parameters were correlated with SUVmax and SUVmean of the renal parenchyma and background activity measured in lung parenchyma, myocardium, gluteal muscle, and the abdominal aorta. Patients were clustered according to their grade of chronic kidney disease (CKD), and a regression analysis and one-way ANOVA were conducted in this retrospective analysis. RESULTS: We found a negative correlation between GFR and [(68) Ga]Ga-FAPI uptake for both SUVmax and SUVmean values, whereas background activity showed no correlation with GFR. [(68) Ga]Ga-DOTATOC and [(68) Ga]Ga-PSMA did not correlate between CKD stage and intra-renal parenchymal radiotracer uptake. Only [(68) Ga]Ga-PSMA background activity exhibited a positive correlation with GFR suggesting an unspecific binding/retention potentially due to longer circulation times. CONCLUSION: There is a significant negative correlation between renal parenchymal [(68) Ga]Ga-FAPI uptake and GFR, which was not the case for [(68) Ga]Ga-DOTATOC and [(68) Ga]Ga-PSMA. This correlation suggests a specific binding of FAPI rather than a potential unspecific retention in the renal parenchyma, underlining the potential value of [(68) Ga]Ga-FAPI for the noninvasive quantitative evaluation of kidney fibrosis. Springer Berlin Heidelberg 2022-01-06 2022 /pmc/articles/PMC9308582/ /pubmed/34988624 http://dx.doi.org/10.1007/s00259-021-05660-1 Text en © The Author(s) 2022, corrected publication 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Conen, Patrick
Pennetta, Francesca
Dendl, Katharina
Hertel, Fabian
Vogg, Andreas
Haberkorn, Uwe
Giesel, Frederik L.
Mottaghy, Felix M.
[(68) Ga]Ga-FAPI uptake correlates with the state of chronic kidney disease
title [(68) Ga]Ga-FAPI uptake correlates with the state of chronic kidney disease
title_full [(68) Ga]Ga-FAPI uptake correlates with the state of chronic kidney disease
title_fullStr [(68) Ga]Ga-FAPI uptake correlates with the state of chronic kidney disease
title_full_unstemmed [(68) Ga]Ga-FAPI uptake correlates with the state of chronic kidney disease
title_short [(68) Ga]Ga-FAPI uptake correlates with the state of chronic kidney disease
title_sort [(68) ga]ga-fapi uptake correlates with the state of chronic kidney disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9308582/
https://www.ncbi.nlm.nih.gov/pubmed/34988624
http://dx.doi.org/10.1007/s00259-021-05660-1
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