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Brain fractalkine-CX3CR1 signalling is anti-obesity system as anorexigenic and anti-inflammatory actions in diet-induced obese mice
Fractalkine is one of the CX3C chemokine family, and it is widely expressed in the brain including the hypothalamus. In the brain, fractalkine is expressed in neurons and binds to a CX3C chemokine receptor 1 (CX3CR1) in microglia. The hypothalamus regulates energy homeostasis of which dysregulation...
Autores principales: | Kawamura, Namiko, Katsuura, Goro, Yamada-Goto, Nobuko, Nakama, Riho, Kambe, Yuki, Miyata, Atsuro, Furuyashiki, Tomoyuki, Narumiya, Shuh, Ogawa, Yoshihiro, Inui, Akio |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9308795/ https://www.ncbi.nlm.nih.gov/pubmed/35871167 http://dx.doi.org/10.1038/s41598-022-16944-3 |
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