Cargando…

Highly mutated monoclonal antibody 3F2 targets a conformational and strain-restricted epitope in human immunodeficiency virus gp41 with significant antibody-dependent cell cytotoxicity

Identifying epitope targets by studying the native antibody (Ab) response can identify potential novel vaccine constructs. Studies suggest that long-term non-progressor (LTNP) subjects have inherent immune mechanisms that help to control viremia and disease progression. To explore a role for antibod...

Descripción completa

Detalles Bibliográficos
Autores principales:	DeCotes, Devin, Baron, Sarah, Hoffman, Jonathon, Garrett, Meghan, Sojar, Hakimuddin, Hicar, Mark D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Vienna 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9308897/ https://www.ncbi.nlm.nih.gov/pubmed/35871426 http://dx.doi.org/10.1007/s00705-022-05518-3

Ejemplares similares

641. Development of Structural Epitope Targeting During B-cell Ontogeny by Exploration of Relatives of Gp41 Structural Epitope Binding Antibody 6F5
por: Baron, Sarah, et al.
Publicado: (2018)

1611 Antibodies to conformational epitopes interfere with T20 fusion inhibition
por: Sojar, Hakimuddin, et al.
Publicado: (2014)

274. Potential HIV vaccine gp41 epitope targeting antibodies identify peptides with similarity to proposed Kawasaki disease related peptide, suggesting non-specific mimotope targeting of acidic amino acid enriched regions
por: Hakimuddin, Sojar, et al.
Publicado: (2023)

406. Cloning Antibodies Against Kawasaki Disease from Acute Plasmablast Responses
por: Baron, Sarah, et al.
Publicado: (2019)

Assessment of Antibody Interference of Enfuvirtide (T20) Function Shows Assay Dependent Variability
por: Smith, Michele, et al.
Publicado: (2018)

1008. Presence of Antibody Dependent Cell Cytotoxicity (ADCC) Functional Antibodies that Target a Complex Gp41 Epitope Correlates with Long-term Non-progression and ADCC is Maintained with Mutants Using Germline Heavy Chain Variable Gene Sequence of VH1-02 Gene
por: Baron, Sarah, et al.
Publicado: (2021)

Identification of Anti-gp41 Monoclonal Antibodies That Effectively Target Cytotoxic Immunoconjugates to Cells Infected with Human Immunodeficiency Virus, Type 1
por: Klug, Grant, et al.
Publicado: (2023)

Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike
por: Lee, Jeong Hyun, et al.
Publicado: (2015)

Human Antibodies that Recognize Novel Immunodominant Quaternary Epitopes on the HIV-1 Env Protein
por: Hicar, Mark D., et al.
Publicado: (2016)

Isolation of Monoclonal Antibodies with Predetermined Conformational Epitope Specificity
por: Sholukh, Anton M., et al.
Publicado: (2012)

Diversification of Specificity after Maturation of the Antibody Response to the HIV gp41 Epitope ELDKWA
por: White, Henry N., et al.
Publicado: (2012)

Neutralizing Antibodies Against a Specific Human Immunodeficiency Virus gp41 Epitope are Associated With Long-term Non-progressor Status
por: Lucar, Olivier, et al.
Publicado: (2017)

Identification of a HIV Gp41-Specific Human Monoclonal Antibody With Potent Antibody-Dependent Cellular Cytotoxicity
por: Yang, Zheng, et al.
Publicado: (2018)

Molecular basis for epitope recognition by non-neutralizing anti-gp41 antibody F240
por: Gohain, Neelakshi, et al.
Publicado: (2016)

Identification of HIV gp41-specific antibodies that mediate killing of infected cells
por: Williams, Katherine L., et al.
Publicado: (2019)

Super Potent Bispecific Llama VHH Antibodies Neutralize HIV via a Combination of gp41 and gp120 Epitopes
por: Strokappe, Nika M., et al.
Publicado: (2019)

Distinct conformational states of HIV-1 gp41 are recognized by neutralizing and non-neutralizing antibodies
por: Frey, Gary, et al.
Publicado: (2010)

Envelope Deglycosylation Enhances Antigenicity of HIV-1 gp41 Epitopes for Both Broad Neutralizing Antibodies and Their Unmutated Ancestor Antibodies
por: Ma, Ben-Jiang, et al.
Publicado: (2011)

Neutralizing Antibodies Targeting HIV-1 gp41
por: Caillat, Christophe, et al.
Publicado: (2020)

Epitopes on the peplomer protein of infectious bronchitis virus strain M41 as defined by monoclonal antibodies
por: Niesters, Hubert G.M., et al.
Publicado: (1987)

Induction of Antibodies in Rhesus Macaques That Recognize a Fusion-Intermediate Conformation of HIV-1 gp41
por: Dennison, S. Moses, et al.
Publicado: (2011)

Conformational plasticity of the HIV-1 gp41 immunodominant region is recognized by multiple non-neutralizing antibodies
por: Cook, Jonathan D., et al.
Publicado: (2022)

Identification and Characterization of a Broadly Cross-Reactive HIV-1 Human Monoclonal Antibody That Binds to Both gp120 and gp41
por: Zhang, Mei-Yun, et al.
Publicado: (2012)

Binding of HIV-1 gp41-Directed Neutralizing and Non-Neutralizing Fragment Antibody Binding Domain (Fab) and Single Chain Variable Fragment (ScFv) Antibodies to the Ectodomain of gp41 in the Pre-Hairpin and Six-Helix Bundle Conformations
por: Louis, John M., et al.
Publicado: (2014)

Maternal Envelope gp41 Ectodomain-Specific Antibodies Are Associated With Increased Mother-to-Child Transmission of Human Immunodeficiency Virus-1
por: Naiman, Nicole E, et al.
Publicado: (2020)

IgA Targeting Human Immunodeficiency Virus-1 Envelope gp41 Triggers Antibody-Dependent Cellular Cytotoxicity Cross-Clade and Cooperates with gp41-Specific IgG to Increase Cell Lysis
por: Duchemin, Maxence, et al.
Publicado: (2018)

Determination of a distinguished interferon gamma epitope recognized by monoclonal antibody relating to autoantibody associated immunodeficiency
por: Yasamut, Umpa, et al.
Publicado: (2022)

OA021-04. HIV-1 gp41 envelope MPER mutation altered epitope conformation in lipid and increased sensitivity to 2F5 and 4E10 neutralizing antibodies
por: Shen, X, et al.
Publicado: (2009)

Assessing the protective efficacy of antibodies to the HIV gp41 region by active vaccination
por: Sharma, SK, et al.
Publicado: (2012)

Dissecting Antibodies with Regards to Linear and Conformational Epitopes
por: Forsström, Björn, et al.
Publicado: (2015)

Immunodiagnostic usefulness of monoclonal antibodies specific to conformational epitopes of Taenia solium oncosphere protein TSOL18
por: Assana, Emmanuel, et al.
Publicado: (2021)

Immunogens Modeling a Fusion-Intermediate Conformation of gp41 Elicit Antibodies to the Membrane Proximal External Region of the HIV Envelope Glycoprotein
por: Vassell, Russell, et al.
Publicado: (2015)

P12-08. Membrane-specific antibodies that simultaneously bind to gp41 of HIV-1 and membrane lipid epitopes are induced by immunization with liposomes
por: Beck, Z, et al.
Publicado: (2009)

Enhancing Exposure of HIV-1 Neutralization Epitopes through Mutations in gp41
por: Blish, Catherine A, et al.
Publicado: (2008)

Epitopes of carcinoembryonic antigen (CEA) defined by monoclonal antibodies.
por: Price, M. R.
Publicado: (1988)

Monoclonal antibody mapping of structural and functional plectin epitopes
Publicado: (1991)

Monoclonal Antibody Recognizing a Core Epitope on Mucin
por: Devine, Peter L., et al.
Publicado: (1998)

Production and Characterization of Mouse Monoclonal Antibodies Recognizing Human Pan-IgG Specific Conformational or Linear Epitopes
por: Hajighasemi, Fatemeh, et al.
Publicado: (2012)

Identification of Neutralizing Monoclonal Antibodies Targeting Novel Conformational Epitopes of the Porcine Epidemic Diarrhoea Virus Spike Protein
por: Chang, Chia-Yu, et al.
Publicado: (2019)

Eliciting broadly neutralizing antibodies against HIV-1 that target gp41 MPER
por: Han, D, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_fiusbocgdd6adh1isqql9i9e9m