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Organoids: a systematic review of ethical issues

Organoids are 3D structures grown from pluripotent stem cells derived from human tissue and serve as in vitro miniature models of human organs. Organoids are expected to revolutionize biomedical research and clinical care. However, organoids are not seen as morally neutral. For instance, tissue dono...

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Autores principales: de Jongh, Dide, Massey, Emma K., Bunnik, Eline M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9308907/
https://www.ncbi.nlm.nih.gov/pubmed/35870991
http://dx.doi.org/10.1186/s13287-022-02950-9
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author de Jongh, Dide
Massey, Emma K.
Bunnik, Eline M.
author_facet de Jongh, Dide
Massey, Emma K.
Bunnik, Eline M.
author_sort de Jongh, Dide
collection PubMed
description Organoids are 3D structures grown from pluripotent stem cells derived from human tissue and serve as in vitro miniature models of human organs. Organoids are expected to revolutionize biomedical research and clinical care. However, organoids are not seen as morally neutral. For instance, tissue donors may perceive enduring personal connections with their organoids, setting higher bars for informed consent and patient participation. Also, several organoid sub-types, e.g., brain organoids and human–animal chimeric organoids, have raised controversy. This systematic review provides an overview of ethical discussions as conducted in the scientific literature on organoids. The review covers both research and clinical applications of organoid technology and discusses the topics informed consent, commercialization, personalized medicine, transplantation, brain organoids, chimeras, and gastruloids. It shows that further ethical research is needed especially on organoid transplantation, to help ensure the responsible development and clinical implementation of this technology in this field. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13287-022-02950-9.
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spelling pubmed-93089072022-07-25 Organoids: a systematic review of ethical issues de Jongh, Dide Massey, Emma K. Bunnik, Eline M. Stem Cell Res Ther Review Organoids are 3D structures grown from pluripotent stem cells derived from human tissue and serve as in vitro miniature models of human organs. Organoids are expected to revolutionize biomedical research and clinical care. However, organoids are not seen as morally neutral. For instance, tissue donors may perceive enduring personal connections with their organoids, setting higher bars for informed consent and patient participation. Also, several organoid sub-types, e.g., brain organoids and human–animal chimeric organoids, have raised controversy. This systematic review provides an overview of ethical discussions as conducted in the scientific literature on organoids. The review covers both research and clinical applications of organoid technology and discusses the topics informed consent, commercialization, personalized medicine, transplantation, brain organoids, chimeras, and gastruloids. It shows that further ethical research is needed especially on organoid transplantation, to help ensure the responsible development and clinical implementation of this technology in this field. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13287-022-02950-9. BioMed Central 2022-07-23 /pmc/articles/PMC9308907/ /pubmed/35870991 http://dx.doi.org/10.1186/s13287-022-02950-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
de Jongh, Dide
Massey, Emma K.
Bunnik, Eline M.
Organoids: a systematic review of ethical issues
title Organoids: a systematic review of ethical issues
title_full Organoids: a systematic review of ethical issues
title_fullStr Organoids: a systematic review of ethical issues
title_full_unstemmed Organoids: a systematic review of ethical issues
title_short Organoids: a systematic review of ethical issues
title_sort organoids: a systematic review of ethical issues
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9308907/
https://www.ncbi.nlm.nih.gov/pubmed/35870991
http://dx.doi.org/10.1186/s13287-022-02950-9
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