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Clinical Profile of SARS-CoV-2-Infected Neonates

Background There are conflicting data on the mother-to-child transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and few studies have described the clinical course of neonates infected with SARS-CoV-2. Objectives This study investigates the mother-to-child transmission rate...

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Autores principales: Kulkarni, Rajesh K, Valvi, Chhaya, Dawre, Rahul, Rajput, Uday, Nagpal, Rema, Deshmukh, Isha, Kamath, Pragathi, Harwani, Richa, Srinivasarangan, Ramya, Sonteke, Somendra, R, Apoorva, Kamble, Savita, Naik, Shilpa, Bhosale, Ramesh, Waghmare, Rakeesh, Modi, Deepak, Gajbhiye, Rahul, Kinikar, Aarti A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9308998/
https://www.ncbi.nlm.nih.gov/pubmed/35898362
http://dx.doi.org/10.7759/cureus.26298
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author Kulkarni, Rajesh K
Valvi, Chhaya
Dawre, Rahul
Rajput, Uday
Nagpal, Rema
Deshmukh, Isha
Kamath, Pragathi
Harwani, Richa
Srinivasarangan, Ramya
Sonteke, Somendra
R, Apoorva
Kamble, Savita
Naik, Shilpa
Bhosale, Ramesh
Waghmare, Rakeesh
Modi, Deepak
Gajbhiye, Rahul
Kinikar, Aarti A
author_facet Kulkarni, Rajesh K
Valvi, Chhaya
Dawre, Rahul
Rajput, Uday
Nagpal, Rema
Deshmukh, Isha
Kamath, Pragathi
Harwani, Richa
Srinivasarangan, Ramya
Sonteke, Somendra
R, Apoorva
Kamble, Savita
Naik, Shilpa
Bhosale, Ramesh
Waghmare, Rakeesh
Modi, Deepak
Gajbhiye, Rahul
Kinikar, Aarti A
author_sort Kulkarni, Rajesh K
collection PubMed
description Background There are conflicting data on the mother-to-child transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and few studies have described the clinical course of neonates infected with SARS-CoV-2. Objectives This study investigates the mother-to-child transmission rate and clinical profile of SARS-CoV-2-infected newborns. Methods Data on 304 newborns of 301 mothers with coronavirus disease 2019 (COVID-19) were prospectively collected and analyzed. Reverse transcription-polymerase chain reaction (RT-PCR) determined the presence of SARS-CoV-2 in the placenta, umbilical cord stump, and nasopharyngeal swabs collected within 24h of birth. Clinical and laboratory data of SARS-CoV-2-infected newborns was entered in a structured proforma. Results A total of 20 neonates (6.5%) were positive for SARS-CoV-2, of which 12 were positive only in the nasopharyngeal swab, four cases had the umbilical stump positive, three were positive in the placenta, and one case was positive in all the three specimens collected. Six of the 20 SARS-CoV-2-positive neonates developed severe symptoms. The SARS-CoV-2-positive symptomatic neonates required a more extended stay in hospital compared to their non-symptomatic infected counterparts. Conclusions A proportion of the babies born to SARS-CoV2-infected mothers tested positive and some of these newborns had severe symptoms.
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spelling pubmed-93089982022-07-26 Clinical Profile of SARS-CoV-2-Infected Neonates Kulkarni, Rajesh K Valvi, Chhaya Dawre, Rahul Rajput, Uday Nagpal, Rema Deshmukh, Isha Kamath, Pragathi Harwani, Richa Srinivasarangan, Ramya Sonteke, Somendra R, Apoorva Kamble, Savita Naik, Shilpa Bhosale, Ramesh Waghmare, Rakeesh Modi, Deepak Gajbhiye, Rahul Kinikar, Aarti A Cureus Pediatrics Background There are conflicting data on the mother-to-child transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and few studies have described the clinical course of neonates infected with SARS-CoV-2. Objectives This study investigates the mother-to-child transmission rate and clinical profile of SARS-CoV-2-infected newborns. Methods Data on 304 newborns of 301 mothers with coronavirus disease 2019 (COVID-19) were prospectively collected and analyzed. Reverse transcription-polymerase chain reaction (RT-PCR) determined the presence of SARS-CoV-2 in the placenta, umbilical cord stump, and nasopharyngeal swabs collected within 24h of birth. Clinical and laboratory data of SARS-CoV-2-infected newborns was entered in a structured proforma. Results A total of 20 neonates (6.5%) were positive for SARS-CoV-2, of which 12 were positive only in the nasopharyngeal swab, four cases had the umbilical stump positive, three were positive in the placenta, and one case was positive in all the three specimens collected. Six of the 20 SARS-CoV-2-positive neonates developed severe symptoms. The SARS-CoV-2-positive symptomatic neonates required a more extended stay in hospital compared to their non-symptomatic infected counterparts. Conclusions A proportion of the babies born to SARS-CoV2-infected mothers tested positive and some of these newborns had severe symptoms. Cureus 2022-06-24 /pmc/articles/PMC9308998/ /pubmed/35898362 http://dx.doi.org/10.7759/cureus.26298 Text en Copyright © 2022, Kulkarni et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Pediatrics
Kulkarni, Rajesh K
Valvi, Chhaya
Dawre, Rahul
Rajput, Uday
Nagpal, Rema
Deshmukh, Isha
Kamath, Pragathi
Harwani, Richa
Srinivasarangan, Ramya
Sonteke, Somendra
R, Apoorva
Kamble, Savita
Naik, Shilpa
Bhosale, Ramesh
Waghmare, Rakeesh
Modi, Deepak
Gajbhiye, Rahul
Kinikar, Aarti A
Clinical Profile of SARS-CoV-2-Infected Neonates
title Clinical Profile of SARS-CoV-2-Infected Neonates
title_full Clinical Profile of SARS-CoV-2-Infected Neonates
title_fullStr Clinical Profile of SARS-CoV-2-Infected Neonates
title_full_unstemmed Clinical Profile of SARS-CoV-2-Infected Neonates
title_short Clinical Profile of SARS-CoV-2-Infected Neonates
title_sort clinical profile of sars-cov-2-infected neonates
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9308998/
https://www.ncbi.nlm.nih.gov/pubmed/35898362
http://dx.doi.org/10.7759/cureus.26298
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