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Boosting corrects a memory B cell defect in SARS-CoV-2 mRNA–vaccinated patients with inflammatory bowel disease

Immunosuppressed patients with inflammatory bowel disease (IBD) generate lower amounts of SARS-CoV-2 spike antibodies after mRNA vaccination than healthy controls. We assessed SARS-CoV-2 spike S1 receptor binding domain–specific (S1-RBD–specific) B lymphocytes to identify the underlying cellular def...

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Detalles Bibliográficos
Autores principales:	Pape, Kathryn A., Dileepan, Thamotharampillai, Matchett, William E., Ellwood, Charles, Stresemann, Samuel, Kabage, Amanda J., Kozysa, Daria, Evert, Clayton, Matson, Michael, Lopez, Sharon, Krueger, Peter D., Graiziger, Carolyn T., Vaughn, Byron P., Shmidt, Eugenia, Rhein, Joshua, Schacker, Timothy W., Bold, Tyler D., Langlois, Ryan A., Khoruts, Alexander, Jenkins, Marc K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309052/ https://www.ncbi.nlm.nih.gov/pubmed/35730567 http://dx.doi.org/10.1172/jci.insight.159618

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