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Age-dependent gray matter demyelination is associated with leptomeningeal neutrophil accumulation

People living with multiple sclerosis (MS) experience episodic CNS white matter lesions instigated by autoreactive T cells. With age, patients with MS show evidence of gray matter demyelination and experience devastating nonremitting symptomology. What drives progression is unclear and studying this...

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Detalles Bibliográficos
Autores principales:	Zuo, Michelle, Fettig, Naomi M., Bernier, Louis-Philippe, Pössnecker, Elisabeth, Spring, Shoshana, Pu, Annie, Ma, Xianjie I., Lee, Dennis S.W., Ward, Lesley A., Sharma, Anshu, Kuhle, Jens, Sled, John G., Pröbstel, Anne-Katrin, MacVicar, Brian A., Osborne, Lisa C., Gommerman, Jennifer L., Ramaglia, Valeria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309059/ https://www.ncbi.nlm.nih.gov/pubmed/35536649 http://dx.doi.org/10.1172/jci.insight.158144

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