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Transhemispheric cortex remodeling promotes forelimb recovery after spinal cord injury

Understanding the reorganization of neural circuits spared after spinal cord injury in the motor cortex and spinal cord would provide insights for developing therapeutics. Using optogenetic mapping, we demonstrated a transhemispheric recruitment of neural circuits in the contralateral cortical M1/M2...

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Autores principales: Wu, Wei, Nguyen, Tyler, Ordaz, Josue D., Zhang, Yiping, Liu, Nai-Kui, Hu, Xinhua, Liu, Yuxiang, Ping, Xingjie, Han, Qi, Wu, Xiangbing, Qu, Wenrui, Gao, Sujuan, Shields, Christopher B., Jin, Xiaoming, Xu, Xiao-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309060/
https://www.ncbi.nlm.nih.gov/pubmed/35552276
http://dx.doi.org/10.1172/jci.insight.158150
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author Wu, Wei
Nguyen, Tyler
Ordaz, Josue D.
Zhang, Yiping
Liu, Nai-Kui
Hu, Xinhua
Liu, Yuxiang
Ping, Xingjie
Han, Qi
Wu, Xiangbing
Qu, Wenrui
Gao, Sujuan
Shields, Christopher B.
Jin, Xiaoming
Xu, Xiao-Ming
author_facet Wu, Wei
Nguyen, Tyler
Ordaz, Josue D.
Zhang, Yiping
Liu, Nai-Kui
Hu, Xinhua
Liu, Yuxiang
Ping, Xingjie
Han, Qi
Wu, Xiangbing
Qu, Wenrui
Gao, Sujuan
Shields, Christopher B.
Jin, Xiaoming
Xu, Xiao-Ming
author_sort Wu, Wei
collection PubMed
description Understanding the reorganization of neural circuits spared after spinal cord injury in the motor cortex and spinal cord would provide insights for developing therapeutics. Using optogenetic mapping, we demonstrated a transhemispheric recruitment of neural circuits in the contralateral cortical M1/M2 area to improve the impaired forelimb function after a cervical 5 right-sided hemisection in mice, a model mimicking the human Brown-Séquard syndrome. This cortical reorganization can be elicited by a selective cortical optogenetic neuromodulation paradigm. Areas of whisker, jaw, and neck, together with the rostral forelimb area, on the motor cortex ipsilateral to the lesion were engaged to control the ipsilesional forelimb in both stimulation and nonstimulation groups 8 weeks following injury. However, significant functional benefits were only seen in the stimulation group. Using anterograde tracing, we further revealed a robust sprouting of the intact corticospinal tract in the spinal cord of those animals receiving optogenetic stimulation. The intraspinal corticospinal axonal sprouting correlated with the forelimb functional recovery. Thus, specific neuromodulation of the cortical neural circuits induced massive neural reorganization both in the motor cortex and spinal cord, constructing an alternative motor pathway in restoring impaired forelimb function.
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spelling pubmed-93090602022-07-27 Transhemispheric cortex remodeling promotes forelimb recovery after spinal cord injury Wu, Wei Nguyen, Tyler Ordaz, Josue D. Zhang, Yiping Liu, Nai-Kui Hu, Xinhua Liu, Yuxiang Ping, Xingjie Han, Qi Wu, Xiangbing Qu, Wenrui Gao, Sujuan Shields, Christopher B. Jin, Xiaoming Xu, Xiao-Ming JCI Insight Research Article Understanding the reorganization of neural circuits spared after spinal cord injury in the motor cortex and spinal cord would provide insights for developing therapeutics. Using optogenetic mapping, we demonstrated a transhemispheric recruitment of neural circuits in the contralateral cortical M1/M2 area to improve the impaired forelimb function after a cervical 5 right-sided hemisection in mice, a model mimicking the human Brown-Séquard syndrome. This cortical reorganization can be elicited by a selective cortical optogenetic neuromodulation paradigm. Areas of whisker, jaw, and neck, together with the rostral forelimb area, on the motor cortex ipsilateral to the lesion were engaged to control the ipsilesional forelimb in both stimulation and nonstimulation groups 8 weeks following injury. However, significant functional benefits were only seen in the stimulation group. Using anterograde tracing, we further revealed a robust sprouting of the intact corticospinal tract in the spinal cord of those animals receiving optogenetic stimulation. The intraspinal corticospinal axonal sprouting correlated with the forelimb functional recovery. Thus, specific neuromodulation of the cortical neural circuits induced massive neural reorganization both in the motor cortex and spinal cord, constructing an alternative motor pathway in restoring impaired forelimb function. American Society for Clinical Investigation 2022-06-22 /pmc/articles/PMC9309060/ /pubmed/35552276 http://dx.doi.org/10.1172/jci.insight.158150 Text en © 2022 Wu et al. https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Article
Wu, Wei
Nguyen, Tyler
Ordaz, Josue D.
Zhang, Yiping
Liu, Nai-Kui
Hu, Xinhua
Liu, Yuxiang
Ping, Xingjie
Han, Qi
Wu, Xiangbing
Qu, Wenrui
Gao, Sujuan
Shields, Christopher B.
Jin, Xiaoming
Xu, Xiao-Ming
Transhemispheric cortex remodeling promotes forelimb recovery after spinal cord injury
title Transhemispheric cortex remodeling promotes forelimb recovery after spinal cord injury
title_full Transhemispheric cortex remodeling promotes forelimb recovery after spinal cord injury
title_fullStr Transhemispheric cortex remodeling promotes forelimb recovery after spinal cord injury
title_full_unstemmed Transhemispheric cortex remodeling promotes forelimb recovery after spinal cord injury
title_short Transhemispheric cortex remodeling promotes forelimb recovery after spinal cord injury
title_sort transhemispheric cortex remodeling promotes forelimb recovery after spinal cord injury
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309060/
https://www.ncbi.nlm.nih.gov/pubmed/35552276
http://dx.doi.org/10.1172/jci.insight.158150
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