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Transhemispheric cortex remodeling promotes forelimb recovery after spinal cord injury
Understanding the reorganization of neural circuits spared after spinal cord injury in the motor cortex and spinal cord would provide insights for developing therapeutics. Using optogenetic mapping, we demonstrated a transhemispheric recruitment of neural circuits in the contralateral cortical M1/M2...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Clinical Investigation
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309060/ https://www.ncbi.nlm.nih.gov/pubmed/35552276 http://dx.doi.org/10.1172/jci.insight.158150 |
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author | Wu, Wei Nguyen, Tyler Ordaz, Josue D. Zhang, Yiping Liu, Nai-Kui Hu, Xinhua Liu, Yuxiang Ping, Xingjie Han, Qi Wu, Xiangbing Qu, Wenrui Gao, Sujuan Shields, Christopher B. Jin, Xiaoming Xu, Xiao-Ming |
author_facet | Wu, Wei Nguyen, Tyler Ordaz, Josue D. Zhang, Yiping Liu, Nai-Kui Hu, Xinhua Liu, Yuxiang Ping, Xingjie Han, Qi Wu, Xiangbing Qu, Wenrui Gao, Sujuan Shields, Christopher B. Jin, Xiaoming Xu, Xiao-Ming |
author_sort | Wu, Wei |
collection | PubMed |
description | Understanding the reorganization of neural circuits spared after spinal cord injury in the motor cortex and spinal cord would provide insights for developing therapeutics. Using optogenetic mapping, we demonstrated a transhemispheric recruitment of neural circuits in the contralateral cortical M1/M2 area to improve the impaired forelimb function after a cervical 5 right-sided hemisection in mice, a model mimicking the human Brown-Séquard syndrome. This cortical reorganization can be elicited by a selective cortical optogenetic neuromodulation paradigm. Areas of whisker, jaw, and neck, together with the rostral forelimb area, on the motor cortex ipsilateral to the lesion were engaged to control the ipsilesional forelimb in both stimulation and nonstimulation groups 8 weeks following injury. However, significant functional benefits were only seen in the stimulation group. Using anterograde tracing, we further revealed a robust sprouting of the intact corticospinal tract in the spinal cord of those animals receiving optogenetic stimulation. The intraspinal corticospinal axonal sprouting correlated with the forelimb functional recovery. Thus, specific neuromodulation of the cortical neural circuits induced massive neural reorganization both in the motor cortex and spinal cord, constructing an alternative motor pathway in restoring impaired forelimb function. |
format | Online Article Text |
id | pubmed-9309060 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Society for Clinical Investigation |
record_format | MEDLINE/PubMed |
spelling | pubmed-93090602022-07-27 Transhemispheric cortex remodeling promotes forelimb recovery after spinal cord injury Wu, Wei Nguyen, Tyler Ordaz, Josue D. Zhang, Yiping Liu, Nai-Kui Hu, Xinhua Liu, Yuxiang Ping, Xingjie Han, Qi Wu, Xiangbing Qu, Wenrui Gao, Sujuan Shields, Christopher B. Jin, Xiaoming Xu, Xiao-Ming JCI Insight Research Article Understanding the reorganization of neural circuits spared after spinal cord injury in the motor cortex and spinal cord would provide insights for developing therapeutics. Using optogenetic mapping, we demonstrated a transhemispheric recruitment of neural circuits in the contralateral cortical M1/M2 area to improve the impaired forelimb function after a cervical 5 right-sided hemisection in mice, a model mimicking the human Brown-Séquard syndrome. This cortical reorganization can be elicited by a selective cortical optogenetic neuromodulation paradigm. Areas of whisker, jaw, and neck, together with the rostral forelimb area, on the motor cortex ipsilateral to the lesion were engaged to control the ipsilesional forelimb in both stimulation and nonstimulation groups 8 weeks following injury. However, significant functional benefits were only seen in the stimulation group. Using anterograde tracing, we further revealed a robust sprouting of the intact corticospinal tract in the spinal cord of those animals receiving optogenetic stimulation. The intraspinal corticospinal axonal sprouting correlated with the forelimb functional recovery. Thus, specific neuromodulation of the cortical neural circuits induced massive neural reorganization both in the motor cortex and spinal cord, constructing an alternative motor pathway in restoring impaired forelimb function. American Society for Clinical Investigation 2022-06-22 /pmc/articles/PMC9309060/ /pubmed/35552276 http://dx.doi.org/10.1172/jci.insight.158150 Text en © 2022 Wu et al. https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Article Wu, Wei Nguyen, Tyler Ordaz, Josue D. Zhang, Yiping Liu, Nai-Kui Hu, Xinhua Liu, Yuxiang Ping, Xingjie Han, Qi Wu, Xiangbing Qu, Wenrui Gao, Sujuan Shields, Christopher B. Jin, Xiaoming Xu, Xiao-Ming Transhemispheric cortex remodeling promotes forelimb recovery after spinal cord injury |
title | Transhemispheric cortex remodeling promotes forelimb recovery after spinal cord injury |
title_full | Transhemispheric cortex remodeling promotes forelimb recovery after spinal cord injury |
title_fullStr | Transhemispheric cortex remodeling promotes forelimb recovery after spinal cord injury |
title_full_unstemmed | Transhemispheric cortex remodeling promotes forelimb recovery after spinal cord injury |
title_short | Transhemispheric cortex remodeling promotes forelimb recovery after spinal cord injury |
title_sort | transhemispheric cortex remodeling promotes forelimb recovery after spinal cord injury |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309060/ https://www.ncbi.nlm.nih.gov/pubmed/35552276 http://dx.doi.org/10.1172/jci.insight.158150 |
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