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The influence of UGT1A1 polymorphisms on modified FOLFIRINOX dose in double-variant-type patients with advanced pancreatic cancer

BACKGROUND: UGT1A1 polymorphisms should be considered when using irinotecan-containing regimens, especially in patients with a double-variant-type (DV), including homozygous for UGT1A1*28 and UGT1A1*6 and heterozygous for both UGT1A1*28 and UGT1A1*6. We investigated the safety and efficacy of modifi...

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Detalles Bibliográficos
Autores principales:	Satake, Tomoyuki, Morizane, Chigusa, Maruki, Yuta, Ohba, Akihiro, Nagashio, Yoshikuni, Kondo, Shunsuke, Hijioka, Susumu, Ueno, Hideki, Okusaka, Takuji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Nature Singapore 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309143/ https://www.ncbi.nlm.nih.gov/pubmed/35637361 http://dx.doi.org/10.1007/s10147-022-02186-w

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