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Autophagy Related Noncoding RNAs: Emerging Regulatory Factors of Gastric Cancer

Gastric cancer (GC) is one of the most common malignant cancers that seriously affect human health. Autophagy is a highly conserved self-defense mechanism found to plays an important role in the occurrence, progression, drug resistance, and prognosis of GC. Noncoding RNAs (ncRNAs) play a critical ro...

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Autores principales: Lu, Ling, Liang, Qiaoyan, Zhang, Xinyi, Xu, Yumeng, Meng, Dehua, Liang, Zhaofeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309173/
https://www.ncbi.nlm.nih.gov/pubmed/35898946
http://dx.doi.org/10.2147/CMAR.S364761
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author Lu, Ling
Liang, Qiaoyan
Zhang, Xinyi
Xu, Yumeng
Meng, Dehua
Liang, Zhaofeng
author_facet Lu, Ling
Liang, Qiaoyan
Zhang, Xinyi
Xu, Yumeng
Meng, Dehua
Liang, Zhaofeng
author_sort Lu, Ling
collection PubMed
description Gastric cancer (GC) is one of the most common malignant cancers that seriously affect human health. Autophagy is a highly conserved self-defense mechanism found to plays an important role in the occurrence, progression, drug resistance, and prognosis of GC. Noncoding RNAs (ncRNAs) play a critical role in the occurrence and development of a variety of diseases including GC. In recent years, increasing attention has been given to research on autophagy-related ncRNAs, such as miRNA, lncRNA, and circRNA in GC. Herein, we briefly summarize the roles, functions, and the research progress of autophagy and autophagy-related ncRNAs in GC with a focus on the potential application in GC tumorigenesis, development, prognosis, and drug resistance. We also discussed prospects of clinical application, future research direction, and challenges in future research of autophagy-related ncRNAs.
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spelling pubmed-93091732022-07-26 Autophagy Related Noncoding RNAs: Emerging Regulatory Factors of Gastric Cancer Lu, Ling Liang, Qiaoyan Zhang, Xinyi Xu, Yumeng Meng, Dehua Liang, Zhaofeng Cancer Manag Res Review Gastric cancer (GC) is one of the most common malignant cancers that seriously affect human health. Autophagy is a highly conserved self-defense mechanism found to plays an important role in the occurrence, progression, drug resistance, and prognosis of GC. Noncoding RNAs (ncRNAs) play a critical role in the occurrence and development of a variety of diseases including GC. In recent years, increasing attention has been given to research on autophagy-related ncRNAs, such as miRNA, lncRNA, and circRNA in GC. Herein, we briefly summarize the roles, functions, and the research progress of autophagy and autophagy-related ncRNAs in GC with a focus on the potential application in GC tumorigenesis, development, prognosis, and drug resistance. We also discussed prospects of clinical application, future research direction, and challenges in future research of autophagy-related ncRNAs. Dove 2022-07-19 /pmc/articles/PMC9309173/ /pubmed/35898946 http://dx.doi.org/10.2147/CMAR.S364761 Text en © 2022 Lu et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Lu, Ling
Liang, Qiaoyan
Zhang, Xinyi
Xu, Yumeng
Meng, Dehua
Liang, Zhaofeng
Autophagy Related Noncoding RNAs: Emerging Regulatory Factors of Gastric Cancer
title Autophagy Related Noncoding RNAs: Emerging Regulatory Factors of Gastric Cancer
title_full Autophagy Related Noncoding RNAs: Emerging Regulatory Factors of Gastric Cancer
title_fullStr Autophagy Related Noncoding RNAs: Emerging Regulatory Factors of Gastric Cancer
title_full_unstemmed Autophagy Related Noncoding RNAs: Emerging Regulatory Factors of Gastric Cancer
title_short Autophagy Related Noncoding RNAs: Emerging Regulatory Factors of Gastric Cancer
title_sort autophagy related noncoding rnas: emerging regulatory factors of gastric cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309173/
https://www.ncbi.nlm.nih.gov/pubmed/35898946
http://dx.doi.org/10.2147/CMAR.S364761
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