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Potassium Channels as a Target for Cancer Therapy: Current Perspectives
Potassium (K(+)) channels are highly regulated membrane proteins that control the potassium ion flux and respond to different cellular stimuli. These ion channels are grouped into three major families, Kv (voltage-gated K(+) channel), Kir (inwardly rectifying K(+) channel) and K2P (two-pore K(+) cha...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309325/ https://www.ncbi.nlm.nih.gov/pubmed/35899081 http://dx.doi.org/10.2147/OTT.S326614 |
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author | Zúñiga, Leandro Cayo, Angel González, Wendy Vilos, Cristian Zúñiga, Rafael |
author_facet | Zúñiga, Leandro Cayo, Angel González, Wendy Vilos, Cristian Zúñiga, Rafael |
author_sort | Zúñiga, Leandro |
collection | PubMed |
description | Potassium (K(+)) channels are highly regulated membrane proteins that control the potassium ion flux and respond to different cellular stimuli. These ion channels are grouped into three major families, Kv (voltage-gated K(+) channel), Kir (inwardly rectifying K(+) channel) and K2P (two-pore K(+) channels), according to the structure, to mediate the K(+) currents. In cancer, alterations in K(+) channel function can promote the acquisition of the so-called hallmarks of cancer – cell proliferation, resistance to apoptosis, metabolic changes, angiogenesis, and migratory capabilities – emerging as targets for the development of new therapeutic drugs. In this review, we focus our attention on the different K(+) channels associated with the most relevant and prevalent cancer types. We summarize our knowledge about the potassium channels structure and function, their cancer dysregulated expression and discuss the K(+) channels modulator and the strategies for designing new drugs. |
format | Online Article Text |
id | pubmed-9309325 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-93093252022-07-26 Potassium Channels as a Target for Cancer Therapy: Current Perspectives Zúñiga, Leandro Cayo, Angel González, Wendy Vilos, Cristian Zúñiga, Rafael Onco Targets Ther Review Potassium (K(+)) channels are highly regulated membrane proteins that control the potassium ion flux and respond to different cellular stimuli. These ion channels are grouped into three major families, Kv (voltage-gated K(+) channel), Kir (inwardly rectifying K(+) channel) and K2P (two-pore K(+) channels), according to the structure, to mediate the K(+) currents. In cancer, alterations in K(+) channel function can promote the acquisition of the so-called hallmarks of cancer – cell proliferation, resistance to apoptosis, metabolic changes, angiogenesis, and migratory capabilities – emerging as targets for the development of new therapeutic drugs. In this review, we focus our attention on the different K(+) channels associated with the most relevant and prevalent cancer types. We summarize our knowledge about the potassium channels structure and function, their cancer dysregulated expression and discuss the K(+) channels modulator and the strategies for designing new drugs. Dove 2022-07-20 /pmc/articles/PMC9309325/ /pubmed/35899081 http://dx.doi.org/10.2147/OTT.S326614 Text en © 2022 Zúñiga et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Review Zúñiga, Leandro Cayo, Angel González, Wendy Vilos, Cristian Zúñiga, Rafael Potassium Channels as a Target for Cancer Therapy: Current Perspectives |
title | Potassium Channels as a Target for Cancer Therapy: Current Perspectives |
title_full | Potassium Channels as a Target for Cancer Therapy: Current Perspectives |
title_fullStr | Potassium Channels as a Target for Cancer Therapy: Current Perspectives |
title_full_unstemmed | Potassium Channels as a Target for Cancer Therapy: Current Perspectives |
title_short | Potassium Channels as a Target for Cancer Therapy: Current Perspectives |
title_sort | potassium channels as a target for cancer therapy: current perspectives |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309325/ https://www.ncbi.nlm.nih.gov/pubmed/35899081 http://dx.doi.org/10.2147/OTT.S326614 |
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