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Acute Neurological Presentation in Children With SARS-CoV-2 Infection
BACKGROUND: In the pediatric population, the knowledge of the acute presentation of SARS-CoV-2 infection is mainly limited to small series and case reports, particularly when dealing with neurological symptoms. We describe a large cohort of children with acute SARS-CoV-2 infection, focusing on the n...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309333/ https://www.ncbi.nlm.nih.gov/pubmed/35899136 http://dx.doi.org/10.3389/fped.2022.909849 |
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author | Riva, Antonella Piccolo, Gianluca Balletti, Federica Binelli, Maria Brolatti, Noemi Verrotti, Alberto Amadori, Elisabetta Spalice, Alberto Giacomini, Thea Mancardi, Maria Margherita Iannetti, Paola Vari, Maria Stella Piccotti, Emanuela Striano, Pasquale Brisca, Giacomo |
author_facet | Riva, Antonella Piccolo, Gianluca Balletti, Federica Binelli, Maria Brolatti, Noemi Verrotti, Alberto Amadori, Elisabetta Spalice, Alberto Giacomini, Thea Mancardi, Maria Margherita Iannetti, Paola Vari, Maria Stella Piccotti, Emanuela Striano, Pasquale Brisca, Giacomo |
author_sort | Riva, Antonella |
collection | PubMed |
description | BACKGROUND: In the pediatric population, the knowledge of the acute presentation of SARS-CoV-2 infection is mainly limited to small series and case reports, particularly when dealing with neurological symptoms. We describe a large cohort of children with acute SARS-CoV-2 infection, focusing on the neurological manifestations and investigating correlations between disease severity and population demographics. METHODS: Patients aged 0–18 years with a positive molecular swab were recruited between April 2020 and March 2021 from a tertiary Italian pediatric centre. Clinical data, imaging, and laboratory test results were retrieved from our local dataset and statistically analyzed. RESULTS: A total of 237 patients with a median age of 3.2 years were eligible; thirty-two (13.5%) presented with neurological symptoms, including headache (65.6%), altered awareness (18.8%), ageusia/anosmia (12.5%), seizures (6.3%), and vertigo (6.3%), combined in 7 (21.9%) cases. Respiratory (59.5%) and gastrointestinal (25.3%) symptoms were the most common among the 205 (86.5%) patients without neurological involvement. Neurological symptoms did not significantly influence the severity of the triage access codes. Moreover, pre-existing medical conditions were not higher in the group with neurological manifestations. Overall, fifty-nine patients (25%, 14/59 with neurological symptoms) required treatment, being antibiotics, systemic steroids, and heparin those most prescribed. CONCLUSION: Our study supports the overall benign course of the SARS-CoV-2 infection in children. Neurological manifestations, except for headache, remain a rare presenting symptom, and disease severity seems unrelated to pre-existing medical conditions. |
format | Online Article Text |
id | pubmed-9309333 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93093332022-07-26 Acute Neurological Presentation in Children With SARS-CoV-2 Infection Riva, Antonella Piccolo, Gianluca Balletti, Federica Binelli, Maria Brolatti, Noemi Verrotti, Alberto Amadori, Elisabetta Spalice, Alberto Giacomini, Thea Mancardi, Maria Margherita Iannetti, Paola Vari, Maria Stella Piccotti, Emanuela Striano, Pasquale Brisca, Giacomo Front Pediatr Pediatrics BACKGROUND: In the pediatric population, the knowledge of the acute presentation of SARS-CoV-2 infection is mainly limited to small series and case reports, particularly when dealing with neurological symptoms. We describe a large cohort of children with acute SARS-CoV-2 infection, focusing on the neurological manifestations and investigating correlations between disease severity and population demographics. METHODS: Patients aged 0–18 years with a positive molecular swab were recruited between April 2020 and March 2021 from a tertiary Italian pediatric centre. Clinical data, imaging, and laboratory test results were retrieved from our local dataset and statistically analyzed. RESULTS: A total of 237 patients with a median age of 3.2 years were eligible; thirty-two (13.5%) presented with neurological symptoms, including headache (65.6%), altered awareness (18.8%), ageusia/anosmia (12.5%), seizures (6.3%), and vertigo (6.3%), combined in 7 (21.9%) cases. Respiratory (59.5%) and gastrointestinal (25.3%) symptoms were the most common among the 205 (86.5%) patients without neurological involvement. Neurological symptoms did not significantly influence the severity of the triage access codes. Moreover, pre-existing medical conditions were not higher in the group with neurological manifestations. Overall, fifty-nine patients (25%, 14/59 with neurological symptoms) required treatment, being antibiotics, systemic steroids, and heparin those most prescribed. CONCLUSION: Our study supports the overall benign course of the SARS-CoV-2 infection in children. Neurological manifestations, except for headache, remain a rare presenting symptom, and disease severity seems unrelated to pre-existing medical conditions. Frontiers Media S.A. 2022-07-11 /pmc/articles/PMC9309333/ /pubmed/35899136 http://dx.doi.org/10.3389/fped.2022.909849 Text en Copyright © 2022 Riva, Piccolo, Balletti, Binelli, Brolatti, Verrotti, Amadori, Spalice, Giacomini, Mancardi, Iannetti, Vari, Piccotti, Striano and Brisca. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pediatrics Riva, Antonella Piccolo, Gianluca Balletti, Federica Binelli, Maria Brolatti, Noemi Verrotti, Alberto Amadori, Elisabetta Spalice, Alberto Giacomini, Thea Mancardi, Maria Margherita Iannetti, Paola Vari, Maria Stella Piccotti, Emanuela Striano, Pasquale Brisca, Giacomo Acute Neurological Presentation in Children With SARS-CoV-2 Infection |
title | Acute Neurological Presentation in Children With SARS-CoV-2 Infection |
title_full | Acute Neurological Presentation in Children With SARS-CoV-2 Infection |
title_fullStr | Acute Neurological Presentation in Children With SARS-CoV-2 Infection |
title_full_unstemmed | Acute Neurological Presentation in Children With SARS-CoV-2 Infection |
title_short | Acute Neurological Presentation in Children With SARS-CoV-2 Infection |
title_sort | acute neurological presentation in children with sars-cov-2 infection |
topic | Pediatrics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309333/ https://www.ncbi.nlm.nih.gov/pubmed/35899136 http://dx.doi.org/10.3389/fped.2022.909849 |
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