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Susceptibility Genes and HLA for Cold Medicine-Related SJS/TEN with SOC
We investigated the genetic predisposition for the pathogenesis of Stevens–Johnson syndrome/epidermal necrolysis with severe ocular complications (SJS/TEN with SOC). Cold medicines (CMs) including multi-ingredient cold-medications and non-steroidal anti-inflammatory drugs (NSAIDs) were implicated in...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309426/ https://www.ncbi.nlm.nih.gov/pubmed/35899189 http://dx.doi.org/10.3389/fgene.2022.912478 |
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author | Ueta, Mayumi |
author_facet | Ueta, Mayumi |
author_sort | Ueta, Mayumi |
collection | PubMed |
description | We investigated the genetic predisposition for the pathogenesis of Stevens–Johnson syndrome/epidermal necrolysis with severe ocular complications (SJS/TEN with SOC). Cold medicines (CMs) including multi-ingredient cold-medications and non-steroidal anti-inflammatory drugs (NSAIDs) were implicated in the development of SJS/TEN with SOC. Studies on the association between HLA genotypes and CM-related SJS/TEN with SOC (CM-SJS/TEN with SOC) revealed an association with HLA-A*02:06 in the Japanese; it may be a marker in Koreans. HLA-B*44:03 was associated with the Japanese, Thais, and Indians; in Brazilians of European ancestry, it may be a positive marker. PTGER3 is a susceptibility gene; HLA-A*02:06 and PTGER3 polymorphisms exerted additive effects in Japanese and Korean patients. A genome-wide association study showed that IKZF1 was associated with the Japanese. A meta-analysis including Japanese, Koreans, Indians, and Brazilians also revealed an association between CM-SJS/TEN with SOC and IKZF1. The upregulation of hsa-miR-628-3p in the plasma of SJS/TEN with SOC patients may suppress the expression of TLR3 and innate immune-related genes. Not only CMs but also the interaction of TLR3, PTGER3, IKZF1, and HLA and maybe some microbial infections are necessary for the onset of SJS/TEN with SOC. |
format | Online Article Text |
id | pubmed-9309426 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93094262022-07-26 Susceptibility Genes and HLA for Cold Medicine-Related SJS/TEN with SOC Ueta, Mayumi Front Genet Genetics We investigated the genetic predisposition for the pathogenesis of Stevens–Johnson syndrome/epidermal necrolysis with severe ocular complications (SJS/TEN with SOC). Cold medicines (CMs) including multi-ingredient cold-medications and non-steroidal anti-inflammatory drugs (NSAIDs) were implicated in the development of SJS/TEN with SOC. Studies on the association between HLA genotypes and CM-related SJS/TEN with SOC (CM-SJS/TEN with SOC) revealed an association with HLA-A*02:06 in the Japanese; it may be a marker in Koreans. HLA-B*44:03 was associated with the Japanese, Thais, and Indians; in Brazilians of European ancestry, it may be a positive marker. PTGER3 is a susceptibility gene; HLA-A*02:06 and PTGER3 polymorphisms exerted additive effects in Japanese and Korean patients. A genome-wide association study showed that IKZF1 was associated with the Japanese. A meta-analysis including Japanese, Koreans, Indians, and Brazilians also revealed an association between CM-SJS/TEN with SOC and IKZF1. The upregulation of hsa-miR-628-3p in the plasma of SJS/TEN with SOC patients may suppress the expression of TLR3 and innate immune-related genes. Not only CMs but also the interaction of TLR3, PTGER3, IKZF1, and HLA and maybe some microbial infections are necessary for the onset of SJS/TEN with SOC. Frontiers Media S.A. 2022-07-11 /pmc/articles/PMC9309426/ /pubmed/35899189 http://dx.doi.org/10.3389/fgene.2022.912478 Text en Copyright © 2022 Ueta. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Ueta, Mayumi Susceptibility Genes and HLA for Cold Medicine-Related SJS/TEN with SOC |
title | Susceptibility Genes and HLA for Cold Medicine-Related SJS/TEN with SOC |
title_full | Susceptibility Genes and HLA for Cold Medicine-Related SJS/TEN with SOC |
title_fullStr | Susceptibility Genes and HLA for Cold Medicine-Related SJS/TEN with SOC |
title_full_unstemmed | Susceptibility Genes and HLA for Cold Medicine-Related SJS/TEN with SOC |
title_short | Susceptibility Genes and HLA for Cold Medicine-Related SJS/TEN with SOC |
title_sort | susceptibility genes and hla for cold medicine-related sjs/ten with soc |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309426/ https://www.ncbi.nlm.nih.gov/pubmed/35899189 http://dx.doi.org/10.3389/fgene.2022.912478 |
work_keys_str_mv | AT uetamayumi susceptibilitygenesandhlaforcoldmedicinerelatedsjstenwithsoc |