A highly D(3)R-selective and efficacious partial agonist (S)-ABS01-113 compared to its D(3)R-selective antagonist enantiomer (R)-ABS01-113 as potential treatments for opioid use disorder

The non-medical use of opioids has become a national crisis in the USA. Developing non-opioid pharmacotherapies for controlling this opioid epidemic is urgent. Dopamine D(3) receptor (D(3)R) antagonists and low efficacy partial agonists have shown promising profiles in animal models of opioid use di...

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Detalles Bibliográficos
Autores principales: Galaj, Ewa, Bi, Guo-Hua, Klein, Benjamin, Hempel, Briana, Shaik, Anver Basha, Gogarnoiu, Emma S., Friedman, Jacob, Lam, Jenny, Rais, Rana, Reed, John F., Bloom, Shelley H., Swanson, Tracy L., Schmachtenberg, Jennifer L., Eshleman, Amy J., Janowsky, Aaron, Xi, Zheng-Xiong, Newman, Amy Hauck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309443/
https://www.ncbi.nlm.nih.gov/pubmed/35879349
http://dx.doi.org/10.1038/s41386-022-01379-1

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