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A Bibliometric Review on Gut Microbiome and Alzheimer’s Disease Between 2012 and 2021

Research on the microbiome has drawn an increasing amount of attention over the past decade. Even more so for its association with disease. Neurodegenerative diseases, such as Alzheimer’s disease (AD) have been a subject of study for a long time with slow success in improving diagnostic accuracy or...

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Detalles Bibliográficos
Autores principales: Trejo-Castro, Alejandro I., Carrion-Alvarez, Diego, Martinez-Torteya, Antonio, Rangel-Escareño, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309471/
https://www.ncbi.nlm.nih.gov/pubmed/35898324
http://dx.doi.org/10.3389/fnagi.2022.804177
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author Trejo-Castro, Alejandro I.
Carrion-Alvarez, Diego
Martinez-Torteya, Antonio
Rangel-Escareño, Claudia
author_facet Trejo-Castro, Alejandro I.
Carrion-Alvarez, Diego
Martinez-Torteya, Antonio
Rangel-Escareño, Claudia
author_sort Trejo-Castro, Alejandro I.
collection PubMed
description Research on the microbiome has drawn an increasing amount of attention over the past decade. Even more so for its association with disease. Neurodegenerative diseases, such as Alzheimer’s disease (AD) have been a subject of study for a long time with slow success in improving diagnostic accuracy or identifying a possibility for treatment. In this work, we analyze past and current research on microbiome and its positive impact on AD treatment and diagnosis. We present a bibliometric analysis from 2012 to 2021 with data retrieved on September 2, 2021, from the Scopus database. The query includes “Gut AND (Microbiota OR Microbiome) AND Alzheimer*” within the article title, abstract, and keywords for all kinds of documents in the database. Compared with 2016, the number of publications (NPs) on the subject doubled by 2017. Moreover, we observe an exponential growth through 2020, and with the data presented, it is almost certain that it will continue this trend and grow even further in the upcoming years. We identify key journals interested in the subject and discuss the articles with most citations, analyzing trends and topics for future research, such as the ability to diagnose the disease and complement the cognitive test with other clinical biomarkers. According to the test, mild cognitive impairment (MCI) is normally considered an initial stage for AD. This test, combined with the role of the gut microbiome in early stages of the disease, may improve the diagnostic accuracy. Based on our findings, there is emerging evidence that microbiota, perhaps more specifically gut microbiota, plays a key role in the pathogenesis of diseases, such as AD.
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spelling pubmed-93094712022-07-26 A Bibliometric Review on Gut Microbiome and Alzheimer’s Disease Between 2012 and 2021 Trejo-Castro, Alejandro I. Carrion-Alvarez, Diego Martinez-Torteya, Antonio Rangel-Escareño, Claudia Front Aging Neurosci Neuroscience Research on the microbiome has drawn an increasing amount of attention over the past decade. Even more so for its association with disease. Neurodegenerative diseases, such as Alzheimer’s disease (AD) have been a subject of study for a long time with slow success in improving diagnostic accuracy or identifying a possibility for treatment. In this work, we analyze past and current research on microbiome and its positive impact on AD treatment and diagnosis. We present a bibliometric analysis from 2012 to 2021 with data retrieved on September 2, 2021, from the Scopus database. The query includes “Gut AND (Microbiota OR Microbiome) AND Alzheimer*” within the article title, abstract, and keywords for all kinds of documents in the database. Compared with 2016, the number of publications (NPs) on the subject doubled by 2017. Moreover, we observe an exponential growth through 2020, and with the data presented, it is almost certain that it will continue this trend and grow even further in the upcoming years. We identify key journals interested in the subject and discuss the articles with most citations, analyzing trends and topics for future research, such as the ability to diagnose the disease and complement the cognitive test with other clinical biomarkers. According to the test, mild cognitive impairment (MCI) is normally considered an initial stage for AD. This test, combined with the role of the gut microbiome in early stages of the disease, may improve the diagnostic accuracy. Based on our findings, there is emerging evidence that microbiota, perhaps more specifically gut microbiota, plays a key role in the pathogenesis of diseases, such as AD. Frontiers Media S.A. 2022-07-11 /pmc/articles/PMC9309471/ /pubmed/35898324 http://dx.doi.org/10.3389/fnagi.2022.804177 Text en Copyright © 2022 Trejo-Castro, Carrion-Alvarez, Martinez-Torteya and Rangel-Escareño. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Trejo-Castro, Alejandro I.
Carrion-Alvarez, Diego
Martinez-Torteya, Antonio
Rangel-Escareño, Claudia
A Bibliometric Review on Gut Microbiome and Alzheimer’s Disease Between 2012 and 2021
title A Bibliometric Review on Gut Microbiome and Alzheimer’s Disease Between 2012 and 2021
title_full A Bibliometric Review on Gut Microbiome and Alzheimer’s Disease Between 2012 and 2021
title_fullStr A Bibliometric Review on Gut Microbiome and Alzheimer’s Disease Between 2012 and 2021
title_full_unstemmed A Bibliometric Review on Gut Microbiome and Alzheimer’s Disease Between 2012 and 2021
title_short A Bibliometric Review on Gut Microbiome and Alzheimer’s Disease Between 2012 and 2021
title_sort bibliometric review on gut microbiome and alzheimer’s disease between 2012 and 2021
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309471/
https://www.ncbi.nlm.nih.gov/pubmed/35898324
http://dx.doi.org/10.3389/fnagi.2022.804177
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