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Non-viral CRISPR activation system targeting VEGF-A and TGF-β1 for enhanced osteogenesis of pre-osteoblasts implanted with dual-crosslinked hydrogel

Healing of large calvarial bone defects remains challenge but may be improved by stimulating bone regeneration of implanted cells. The aim of this study is to specially co-activate transforming growth factor β1 (TGF-β1) and vascular endothelial growth factor (VEGF-A) genes expressions in pre-osteobl...

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Detalles Bibliográficos
Autores principales:	Chen, Guo, Deng, Shaohui, Zuo, Mingxiang, Wang, Jin, Cheng, Du, Chen, Bin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Full Length Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309523/ https://www.ncbi.nlm.nih.gov/pubmed/35898441 http://dx.doi.org/10.1016/j.mtbio.2022.100356

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