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An Attention-Based CoT-ResNet With Channel Shuffle Mechanism for Classification of Alzheimer’s Disease Levels

Detection of early morphological changes in the brain and early diagnosis are important for Alzheimer’s disease (AD), and high-resolution magnetic resonance imaging (MRI) can be used to help diagnose and predict the disease. In this paper, we proposed two improved ResNet algorithms that introduced t...

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Autores principales: Li, Chao, Wang, Quan, Liu, Xuebin, Hu, Bingliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309569/
https://www.ncbi.nlm.nih.gov/pubmed/35898323
http://dx.doi.org/10.3389/fnagi.2022.930584
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author Li, Chao
Wang, Quan
Liu, Xuebin
Hu, Bingliang
author_facet Li, Chao
Wang, Quan
Liu, Xuebin
Hu, Bingliang
author_sort Li, Chao
collection PubMed
description Detection of early morphological changes in the brain and early diagnosis are important for Alzheimer’s disease (AD), and high-resolution magnetic resonance imaging (MRI) can be used to help diagnose and predict the disease. In this paper, we proposed two improved ResNet algorithms that introduced the Contextual Transformer (CoT) module, group convolution, and Channel Shuffle mechanism into the traditional ResNet residual blocks. The CoT module is used to replace the 3 × 3 convolution in the residual block to enhance the feature extraction capability of the residual block, while the Channel Shuffle mechanism is used to reorganize the feature maps of different groups in the input layer to improve the communication between the feature maps from different groups. Images of 503 subjects, including 116 healthy controls (HC), 187 subjects with mild cognitive impairment (MCI), and 200 subjects with AD, were selected and collated from the ADNI database, and then, the data were pre-processed and sliced. After that, 10,060 slices were obtained and the three groups of AD, MCI and HC were classified using the improved algorithms. The experiments showed that the refined ResNet-18-based algorithm improved the top-1 accuracy by 2.06%, 0.33%, 1.82%, and 1.52% over the traditional ResNet-18 algorithm for four medical image classification tasks, namely AD: MCI, AD: HC, MCI: HC, and AD: MCI: HC, respectively. The enhanced ResNet-50-based algorithm improved the top-1 accuracy by 1.02%, 2.92%, 3.30%, and 1.31%, respectively, over the traditional ResNet-50 algorithm in four medical image classification tasks, demonstrating the effectiveness of the CoT module replacement and the inclusion of the channel shuffling mechanism, as well as the competitiveness of the improved algorithms.
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spelling pubmed-93095692022-07-26 An Attention-Based CoT-ResNet With Channel Shuffle Mechanism for Classification of Alzheimer’s Disease Levels Li, Chao Wang, Quan Liu, Xuebin Hu, Bingliang Front Aging Neurosci Neuroscience Detection of early morphological changes in the brain and early diagnosis are important for Alzheimer’s disease (AD), and high-resolution magnetic resonance imaging (MRI) can be used to help diagnose and predict the disease. In this paper, we proposed two improved ResNet algorithms that introduced the Contextual Transformer (CoT) module, group convolution, and Channel Shuffle mechanism into the traditional ResNet residual blocks. The CoT module is used to replace the 3 × 3 convolution in the residual block to enhance the feature extraction capability of the residual block, while the Channel Shuffle mechanism is used to reorganize the feature maps of different groups in the input layer to improve the communication between the feature maps from different groups. Images of 503 subjects, including 116 healthy controls (HC), 187 subjects with mild cognitive impairment (MCI), and 200 subjects with AD, were selected and collated from the ADNI database, and then, the data were pre-processed and sliced. After that, 10,060 slices were obtained and the three groups of AD, MCI and HC were classified using the improved algorithms. The experiments showed that the refined ResNet-18-based algorithm improved the top-1 accuracy by 2.06%, 0.33%, 1.82%, and 1.52% over the traditional ResNet-18 algorithm for four medical image classification tasks, namely AD: MCI, AD: HC, MCI: HC, and AD: MCI: HC, respectively. The enhanced ResNet-50-based algorithm improved the top-1 accuracy by 1.02%, 2.92%, 3.30%, and 1.31%, respectively, over the traditional ResNet-50 algorithm in four medical image classification tasks, demonstrating the effectiveness of the CoT module replacement and the inclusion of the channel shuffling mechanism, as well as the competitiveness of the improved algorithms. Frontiers Media S.A. 2022-07-11 /pmc/articles/PMC9309569/ /pubmed/35898323 http://dx.doi.org/10.3389/fnagi.2022.930584 Text en Copyright © 2022 Li, Wang, Liu and Hu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Li, Chao
Wang, Quan
Liu, Xuebin
Hu, Bingliang
An Attention-Based CoT-ResNet With Channel Shuffle Mechanism for Classification of Alzheimer’s Disease Levels
title An Attention-Based CoT-ResNet With Channel Shuffle Mechanism for Classification of Alzheimer’s Disease Levels
title_full An Attention-Based CoT-ResNet With Channel Shuffle Mechanism for Classification of Alzheimer’s Disease Levels
title_fullStr An Attention-Based CoT-ResNet With Channel Shuffle Mechanism for Classification of Alzheimer’s Disease Levels
title_full_unstemmed An Attention-Based CoT-ResNet With Channel Shuffle Mechanism for Classification of Alzheimer’s Disease Levels
title_short An Attention-Based CoT-ResNet With Channel Shuffle Mechanism for Classification of Alzheimer’s Disease Levels
title_sort attention-based cot-resnet with channel shuffle mechanism for classification of alzheimer’s disease levels
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309569/
https://www.ncbi.nlm.nih.gov/pubmed/35898323
http://dx.doi.org/10.3389/fnagi.2022.930584
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