Cargando…

Sexual Dimorphism in Transcriptional and Functional Glucocorticoid Effects on Mouse Skeletal Muscle

Muscle atrophy is common in patients with increased glucocorticoid exposure. Glucocorticoid effects are often sex-specific, and while different glucocorticoid responses between male and female subjects are reported, it is unclear why this is. In this study, we evaluated the effects of corticosterone...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Sheng, Schönke, Milena, Buurstede, Jacobus C., Moll, Tijmen J.A., Gentenaar, Max, Schilperoort, Maaike, Visser, Jenny A., Kaikaew, Kasiphak, van de Vijver, Davy, Abbassi-Daloii, Tooba, Raz, Vered, Aartsma-Rus, Annemieke, van Putten, Maaike, Meijer, Onno C., Kroon, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309696/
https://www.ncbi.nlm.nih.gov/pubmed/35898460
http://dx.doi.org/10.3389/fendo.2022.907908
_version_ 1784753224339685376
author Li, Sheng
Schönke, Milena
Buurstede, Jacobus C.
Moll, Tijmen J.A.
Gentenaar, Max
Schilperoort, Maaike
Visser, Jenny A.
Kaikaew, Kasiphak
van de Vijver, Davy
Abbassi-Daloii, Tooba
Raz, Vered
Aartsma-Rus, Annemieke
van Putten, Maaike
Meijer, Onno C.
Kroon, Jan
author_facet Li, Sheng
Schönke, Milena
Buurstede, Jacobus C.
Moll, Tijmen J.A.
Gentenaar, Max
Schilperoort, Maaike
Visser, Jenny A.
Kaikaew, Kasiphak
van de Vijver, Davy
Abbassi-Daloii, Tooba
Raz, Vered
Aartsma-Rus, Annemieke
van Putten, Maaike
Meijer, Onno C.
Kroon, Jan
author_sort Li, Sheng
collection PubMed
description Muscle atrophy is common in patients with increased glucocorticoid exposure. Glucocorticoid effects are often sex-specific, and while different glucocorticoid responses between male and female subjects are reported, it is unclear why this is. In this study, we evaluated the effects of corticosterone and synthetic glucocorticoid treatment on muscle atrophy in male and female mice. We found that corticosterone treatment reduced grip strength in female mice only, whereas muscle mass was reduced in both sexes. Skeletal muscle transcriptional responses to corticosterone treatment were more pronounced and widespread in male mice. Synthetic glucocorticoid treatment reduced grip strength in both sexes, while female mice were more sensitive to muscle atrophy than male mice. To evaluate the role of androgens, chemically-castrated male mice were treated with synthetic glucocorticoids. We observed additively reduced muscle mass, but did not observe any interaction effects. Although sex differences in glucocorticoid responses in skeletal muscle are partly influenced by androgen signaling, further studies are warranted to fully delineate the underlying mechanisms.
format Online
Article
Text
id pubmed-9309696
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-93096962022-07-26 Sexual Dimorphism in Transcriptional and Functional Glucocorticoid Effects on Mouse Skeletal Muscle Li, Sheng Schönke, Milena Buurstede, Jacobus C. Moll, Tijmen J.A. Gentenaar, Max Schilperoort, Maaike Visser, Jenny A. Kaikaew, Kasiphak van de Vijver, Davy Abbassi-Daloii, Tooba Raz, Vered Aartsma-Rus, Annemieke van Putten, Maaike Meijer, Onno C. Kroon, Jan Front Endocrinol (Lausanne) Endocrinology Muscle atrophy is common in patients with increased glucocorticoid exposure. Glucocorticoid effects are often sex-specific, and while different glucocorticoid responses between male and female subjects are reported, it is unclear why this is. In this study, we evaluated the effects of corticosterone and synthetic glucocorticoid treatment on muscle atrophy in male and female mice. We found that corticosterone treatment reduced grip strength in female mice only, whereas muscle mass was reduced in both sexes. Skeletal muscle transcriptional responses to corticosterone treatment were more pronounced and widespread in male mice. Synthetic glucocorticoid treatment reduced grip strength in both sexes, while female mice were more sensitive to muscle atrophy than male mice. To evaluate the role of androgens, chemically-castrated male mice were treated with synthetic glucocorticoids. We observed additively reduced muscle mass, but did not observe any interaction effects. Although sex differences in glucocorticoid responses in skeletal muscle are partly influenced by androgen signaling, further studies are warranted to fully delineate the underlying mechanisms. Frontiers Media S.A. 2022-07-11 /pmc/articles/PMC9309696/ /pubmed/35898460 http://dx.doi.org/10.3389/fendo.2022.907908 Text en Copyright © 2022 Li, Schönke, Buurstede, Moll, Gentenaar, Schilperoort, Visser, Kaikaew, van de Vijver, Abbassi-Daloii, Raz, Aartsma-Rus, van Putten, Meijer and Kroon https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Li, Sheng
Schönke, Milena
Buurstede, Jacobus C.
Moll, Tijmen J.A.
Gentenaar, Max
Schilperoort, Maaike
Visser, Jenny A.
Kaikaew, Kasiphak
van de Vijver, Davy
Abbassi-Daloii, Tooba
Raz, Vered
Aartsma-Rus, Annemieke
van Putten, Maaike
Meijer, Onno C.
Kroon, Jan
Sexual Dimorphism in Transcriptional and Functional Glucocorticoid Effects on Mouse Skeletal Muscle
title Sexual Dimorphism in Transcriptional and Functional Glucocorticoid Effects on Mouse Skeletal Muscle
title_full Sexual Dimorphism in Transcriptional and Functional Glucocorticoid Effects on Mouse Skeletal Muscle
title_fullStr Sexual Dimorphism in Transcriptional and Functional Glucocorticoid Effects on Mouse Skeletal Muscle
title_full_unstemmed Sexual Dimorphism in Transcriptional and Functional Glucocorticoid Effects on Mouse Skeletal Muscle
title_short Sexual Dimorphism in Transcriptional and Functional Glucocorticoid Effects on Mouse Skeletal Muscle
title_sort sexual dimorphism in transcriptional and functional glucocorticoid effects on mouse skeletal muscle
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309696/
https://www.ncbi.nlm.nih.gov/pubmed/35898460
http://dx.doi.org/10.3389/fendo.2022.907908
work_keys_str_mv AT lisheng sexualdimorphismintranscriptionalandfunctionalglucocorticoideffectsonmouseskeletalmuscle
AT schonkemilena sexualdimorphismintranscriptionalandfunctionalglucocorticoideffectsonmouseskeletalmuscle
AT buurstedejacobusc sexualdimorphismintranscriptionalandfunctionalglucocorticoideffectsonmouseskeletalmuscle
AT molltijmenja sexualdimorphismintranscriptionalandfunctionalglucocorticoideffectsonmouseskeletalmuscle
AT gentenaarmax sexualdimorphismintranscriptionalandfunctionalglucocorticoideffectsonmouseskeletalmuscle
AT schilperoortmaaike sexualdimorphismintranscriptionalandfunctionalglucocorticoideffectsonmouseskeletalmuscle
AT visserjennya sexualdimorphismintranscriptionalandfunctionalglucocorticoideffectsonmouseskeletalmuscle
AT kaikaewkasiphak sexualdimorphismintranscriptionalandfunctionalglucocorticoideffectsonmouseskeletalmuscle
AT vandevijverdavy sexualdimorphismintranscriptionalandfunctionalglucocorticoideffectsonmouseskeletalmuscle
AT abbassidaloiitooba sexualdimorphismintranscriptionalandfunctionalglucocorticoideffectsonmouseskeletalmuscle
AT razvered sexualdimorphismintranscriptionalandfunctionalglucocorticoideffectsonmouseskeletalmuscle
AT aartsmarusannemieke sexualdimorphismintranscriptionalandfunctionalglucocorticoideffectsonmouseskeletalmuscle
AT vanputtenmaaike sexualdimorphismintranscriptionalandfunctionalglucocorticoideffectsonmouseskeletalmuscle
AT meijeronnoc sexualdimorphismintranscriptionalandfunctionalglucocorticoideffectsonmouseskeletalmuscle
AT kroonjan sexualdimorphismintranscriptionalandfunctionalglucocorticoideffectsonmouseskeletalmuscle