AKT1 mediates multiple phosphorylation events that functionally promote HSF1 activation

The heat stress response activates the transcription factor heat shock factor 1 (HSF1), which subsequently upregulates heat shock proteins to maintain the integrity of the proteome. HSF1 activation requires nuclear localization, trimerization, DNA binding, phosphorylation and gene transactivation. P...

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Detalles Bibliográficos
Autores principales: Lu, Wen‐Cheng, Omari, Ramsey, Ray, Haimanti, Wang, John, Williams, Imade, Jacobs, Curteisha, Hockaden, Natasha, Bochman, Matthew L., Carpenter, Richard L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309721/
https://www.ncbi.nlm.nih.gov/pubmed/35080342
http://dx.doi.org/10.1111/febs.16375

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