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Immune Cell and Biochemical Biomarkers in Advanced Laryngeal Cancer
OBJECTIVE: The aim of this study was to evaluate cell and biochemical biomarkers and establish their prognostic value in patients with advanced laryngeal cancer. MATERIAL AND METHODS: A prospective study included 52 patients with advanced laryngeal carcinoma surgically treated at the tertiary referr...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309787/ https://www.ncbi.nlm.nih.gov/pubmed/35898723 http://dx.doi.org/10.1177/15593258221115537 |
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author | Jotic, Ana Milovanovic, Jovica Savic-Vujovic, Katarina Radin, Zorana Medic, Branislava Folic, Miljan Pavlovic, Bojan Vujovic, Aleksandar Dundjerovic, Dusko |
author_facet | Jotic, Ana Milovanovic, Jovica Savic-Vujovic, Katarina Radin, Zorana Medic, Branislava Folic, Miljan Pavlovic, Bojan Vujovic, Aleksandar Dundjerovic, Dusko |
author_sort | Jotic, Ana |
collection | PubMed |
description | OBJECTIVE: The aim of this study was to evaluate cell and biochemical biomarkers and establish their prognostic value in patients with advanced laryngeal cancer. MATERIAL AND METHODS: A prospective study included 52 patients with advanced laryngeal carcinoma surgically treated at the tertiary referral center. Tumor tissue was immunohistochemically stained for T-cell markers (CD4 and CD8), and levels of cytokines (IL-6 and IL-8) and C-reactive protein were analyzed from blood samples. RESULTS: Overall 3-year survival (OS) of patients included in the study was 69.2% and the disease specific survival (DSS) 72.5%. Higher expression of CD4(+) and CD8(+) were significant prognostic factors with positive impact on both OS and DSS in univariate analysis, but not in multivariate analysis. Levels of IL-8 were a significant predictor of 3-year OS and DSS survival in patients with advanced laryngeal cancer but not levels of IL-6 and CRP values. CONCLUSION: Though high expression of CD4 and CD8 were demonstrated in the tumor tissue, but their prognostic role was not established. Higher values of IL-8 proved to be significant negative predictor of DSS. This could further collaborate the inclusion of combination of biomarkers in assessment of favorable treatment choice in patients with advanced laryngeal carcinoma. |
format | Online Article Text |
id | pubmed-9309787 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-93097872022-07-26 Immune Cell and Biochemical Biomarkers in Advanced Laryngeal Cancer Jotic, Ana Milovanovic, Jovica Savic-Vujovic, Katarina Radin, Zorana Medic, Branislava Folic, Miljan Pavlovic, Bojan Vujovic, Aleksandar Dundjerovic, Dusko Dose Response Inflammatory Parameters as Early Biomarkers in Prediction and Monitoring of Therapeutic Effects in Preclinical and Clinical Studies OBJECTIVE: The aim of this study was to evaluate cell and biochemical biomarkers and establish their prognostic value in patients with advanced laryngeal cancer. MATERIAL AND METHODS: A prospective study included 52 patients with advanced laryngeal carcinoma surgically treated at the tertiary referral center. Tumor tissue was immunohistochemically stained for T-cell markers (CD4 and CD8), and levels of cytokines (IL-6 and IL-8) and C-reactive protein were analyzed from blood samples. RESULTS: Overall 3-year survival (OS) of patients included in the study was 69.2% and the disease specific survival (DSS) 72.5%. Higher expression of CD4(+) and CD8(+) were significant prognostic factors with positive impact on both OS and DSS in univariate analysis, but not in multivariate analysis. Levels of IL-8 were a significant predictor of 3-year OS and DSS survival in patients with advanced laryngeal cancer but not levels of IL-6 and CRP values. CONCLUSION: Though high expression of CD4 and CD8 were demonstrated in the tumor tissue, but their prognostic role was not established. Higher values of IL-8 proved to be significant negative predictor of DSS. This could further collaborate the inclusion of combination of biomarkers in assessment of favorable treatment choice in patients with advanced laryngeal carcinoma. SAGE Publications 2022-07-19 /pmc/articles/PMC9309787/ /pubmed/35898723 http://dx.doi.org/10.1177/15593258221115537 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Inflammatory Parameters as Early Biomarkers in Prediction and Monitoring of Therapeutic Effects in Preclinical and Clinical Studies Jotic, Ana Milovanovic, Jovica Savic-Vujovic, Katarina Radin, Zorana Medic, Branislava Folic, Miljan Pavlovic, Bojan Vujovic, Aleksandar Dundjerovic, Dusko Immune Cell and Biochemical Biomarkers in Advanced Laryngeal Cancer |
title | Immune Cell and Biochemical Biomarkers in Advanced Laryngeal
Cancer |
title_full | Immune Cell and Biochemical Biomarkers in Advanced Laryngeal
Cancer |
title_fullStr | Immune Cell and Biochemical Biomarkers in Advanced Laryngeal
Cancer |
title_full_unstemmed | Immune Cell and Biochemical Biomarkers in Advanced Laryngeal
Cancer |
title_short | Immune Cell and Biochemical Biomarkers in Advanced Laryngeal
Cancer |
title_sort | immune cell and biochemical biomarkers in advanced laryngeal
cancer |
topic | Inflammatory Parameters as Early Biomarkers in Prediction and Monitoring of Therapeutic Effects in Preclinical and Clinical Studies |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309787/ https://www.ncbi.nlm.nih.gov/pubmed/35898723 http://dx.doi.org/10.1177/15593258221115537 |
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