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Cutaneous Leishmaniasis Treated with Miltefosine: A Case Series of 10 Paediatric Patients

Cutaneous leishmaniasis poses a therapeutic challenge in the paediatric population. The aim of this study was to assess the efficacy and safety of miltefosine treatment for Old World cutaneous leishmaniasis in paediatric patients. A multicentre retrospective review of 10 children (≤18 years of age)...

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Autores principales: OLLECH, Ayelet, SOLOMON, Michal, HOREV, Amir, REISS-HUSS, Shiran, BEN-AMITAI, Dan, ZVULUNOV, Alex, FRIEDLAND, Rivka, ATAR-SNIR, Vered, PESSACH-MOLCHO, Vered, BARZILAI, Aviv, GREENBERGER, Shoshana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Publication of Acta Dermato-Venereologica 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309834/
https://www.ncbi.nlm.nih.gov/pubmed/33074340
http://dx.doi.org/10.2340/00015555-3669
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author OLLECH, Ayelet
SOLOMON, Michal
HOREV, Amir
REISS-HUSS, Shiran
BEN-AMITAI, Dan
ZVULUNOV, Alex
FRIEDLAND, Rivka
ATAR-SNIR, Vered
PESSACH-MOLCHO, Vered
BARZILAI, Aviv
GREENBERGER, Shoshana
author_facet OLLECH, Ayelet
SOLOMON, Michal
HOREV, Amir
REISS-HUSS, Shiran
BEN-AMITAI, Dan
ZVULUNOV, Alex
FRIEDLAND, Rivka
ATAR-SNIR, Vered
PESSACH-MOLCHO, Vered
BARZILAI, Aviv
GREENBERGER, Shoshana
author_sort OLLECH, Ayelet
collection PubMed
description Cutaneous leishmaniasis poses a therapeutic challenge in the paediatric population. The aim of this study was to assess the efficacy and safety of miltefosine treatment for Old World cutaneous leishmaniasis in paediatric patients. A multicentre retrospective review of 10 children (≤18 years of age) with cutaneous leishmaniasis treated with miltefosine in Israel was performed. Mean ± standard deviation age at diagnosis was 9.1 ± 5.0 years. The Leishmania species diagnosed was L. tropica in 8 cases and Leishmania major in 2 cases. Mean ± standard deviation duration of treatment was 44.8 ± 20.6 days, with a mean follow-up period of 12.1 ± 17.1 months. Complete response was noted in 8 (80%) patients. Treatment failure was noted in 2 (20%) cases. Side-effects related to the medication were minimal. In conclusion, oral miltefosine may be an effective and safe treatment for Old World cutaneous leishmaniasis caused by Leishmania tropica or Leishmania major in children. However, further studies are warranted to draw a definite conclusion.
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spelling pubmed-93098342022-10-20 Cutaneous Leishmaniasis Treated with Miltefosine: A Case Series of 10 Paediatric Patients OLLECH, Ayelet SOLOMON, Michal HOREV, Amir REISS-HUSS, Shiran BEN-AMITAI, Dan ZVULUNOV, Alex FRIEDLAND, Rivka ATAR-SNIR, Vered PESSACH-MOLCHO, Vered BARZILAI, Aviv GREENBERGER, Shoshana Acta Derm Venereol Clinical Report Cutaneous leishmaniasis poses a therapeutic challenge in the paediatric population. The aim of this study was to assess the efficacy and safety of miltefosine treatment for Old World cutaneous leishmaniasis in paediatric patients. A multicentre retrospective review of 10 children (≤18 years of age) with cutaneous leishmaniasis treated with miltefosine in Israel was performed. Mean ± standard deviation age at diagnosis was 9.1 ± 5.0 years. The Leishmania species diagnosed was L. tropica in 8 cases and Leishmania major in 2 cases. Mean ± standard deviation duration of treatment was 44.8 ± 20.6 days, with a mean follow-up period of 12.1 ± 17.1 months. Complete response was noted in 8 (80%) patients. Treatment failure was noted in 2 (20%) cases. Side-effects related to the medication were minimal. In conclusion, oral miltefosine may be an effective and safe treatment for Old World cutaneous leishmaniasis caused by Leishmania tropica or Leishmania major in children. However, further studies are warranted to draw a definite conclusion. Society for Publication of Acta Dermato-Venereologica 2020-11-18 /pmc/articles/PMC9309834/ /pubmed/33074340 http://dx.doi.org/10.2340/00015555-3669 Text en © 2020 Acta Dermato-Venereologica https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the CC BY-NC license
spellingShingle Clinical Report
OLLECH, Ayelet
SOLOMON, Michal
HOREV, Amir
REISS-HUSS, Shiran
BEN-AMITAI, Dan
ZVULUNOV, Alex
FRIEDLAND, Rivka
ATAR-SNIR, Vered
PESSACH-MOLCHO, Vered
BARZILAI, Aviv
GREENBERGER, Shoshana
Cutaneous Leishmaniasis Treated with Miltefosine: A Case Series of 10 Paediatric Patients
title Cutaneous Leishmaniasis Treated with Miltefosine: A Case Series of 10 Paediatric Patients
title_full Cutaneous Leishmaniasis Treated with Miltefosine: A Case Series of 10 Paediatric Patients
title_fullStr Cutaneous Leishmaniasis Treated with Miltefosine: A Case Series of 10 Paediatric Patients
title_full_unstemmed Cutaneous Leishmaniasis Treated with Miltefosine: A Case Series of 10 Paediatric Patients
title_short Cutaneous Leishmaniasis Treated with Miltefosine: A Case Series of 10 Paediatric Patients
title_sort cutaneous leishmaniasis treated with miltefosine: a case series of 10 paediatric patients
topic Clinical Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309834/
https://www.ncbi.nlm.nih.gov/pubmed/33074340
http://dx.doi.org/10.2340/00015555-3669
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