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Longitudinal Changes in Skin Microbiome Associated with Change in Skin Status in Patients with Psoriasis
The aim of this study was to identify key microbes associated with change in skin status (lesional vs normal). Longitudinal changes in the skin microbiome between patients with psoriasis and healthy family controls living in the same household were studied using whole genome metagenomic shotgun sequ...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Society for Publication of Acta Dermato-Venereologica
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309860/ https://www.ncbi.nlm.nih.gov/pubmed/32945341 http://dx.doi.org/10.2340/00015555-3638 |
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author | WANG, Hailun CHAN, W. M. Mandy CHAN, Henry H. PANG, Herbert |
author_facet | WANG, Hailun CHAN, W. M. Mandy CHAN, Henry H. PANG, Herbert |
author_sort | WANG, Hailun |
collection | PubMed |
description | The aim of this study was to identify key microbes associated with change in skin status (lesional vs normal). Longitudinal changes in the skin microbiome between patients with psoriasis and healthy family controls living in the same household were studied using whole genome metagenomic shotgun sequencing at 4 time-points. There were significant changes in abundance of the pathogen Campylobacter jejuni and its higher taxonomic levels when the skin status of patients with psoriasis changed. There were significant longitudinal variations in alpha diveristy (p < 0.001) and beta diversity (p < 0.05) of the skin microbiome in patients with psoriasis, but not in the healthy control group, which indicated composition of skin microbiome in patients with psoriasis was different from healthy control and was dynamically less stable. This study will serve as the basis for future temporal studies of the skin microbiome and probiotic therapeutics. |
format | Online Article Text |
id | pubmed-9309860 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Society for Publication of Acta Dermato-Venereologica |
record_format | MEDLINE/PubMed |
spelling | pubmed-93098602022-10-20 Longitudinal Changes in Skin Microbiome Associated with Change in Skin Status in Patients with Psoriasis WANG, Hailun CHAN, W. M. Mandy CHAN, Henry H. PANG, Herbert Acta Derm Venereol Investigative Report The aim of this study was to identify key microbes associated with change in skin status (lesional vs normal). Longitudinal changes in the skin microbiome between patients with psoriasis and healthy family controls living in the same household were studied using whole genome metagenomic shotgun sequencing at 4 time-points. There were significant changes in abundance of the pathogen Campylobacter jejuni and its higher taxonomic levels when the skin status of patients with psoriasis changed. There were significant longitudinal variations in alpha diveristy (p < 0.001) and beta diversity (p < 0.05) of the skin microbiome in patients with psoriasis, but not in the healthy control group, which indicated composition of skin microbiome in patients with psoriasis was different from healthy control and was dynamically less stable. This study will serve as the basis for future temporal studies of the skin microbiome and probiotic therapeutics. Society for Publication of Acta Dermato-Venereologica 2020-11-24 /pmc/articles/PMC9309860/ /pubmed/32945341 http://dx.doi.org/10.2340/00015555-3638 Text en © 2020 Acta Dermato-Venereologica https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the CC BY-NC license |
spellingShingle | Investigative Report WANG, Hailun CHAN, W. M. Mandy CHAN, Henry H. PANG, Herbert Longitudinal Changes in Skin Microbiome Associated with Change in Skin Status in Patients with Psoriasis |
title | Longitudinal Changes in Skin Microbiome Associated with Change in Skin Status in Patients with Psoriasis |
title_full | Longitudinal Changes in Skin Microbiome Associated with Change in Skin Status in Patients with Psoriasis |
title_fullStr | Longitudinal Changes in Skin Microbiome Associated with Change in Skin Status in Patients with Psoriasis |
title_full_unstemmed | Longitudinal Changes in Skin Microbiome Associated with Change in Skin Status in Patients with Psoriasis |
title_short | Longitudinal Changes in Skin Microbiome Associated with Change in Skin Status in Patients with Psoriasis |
title_sort | longitudinal changes in skin microbiome associated with change in skin status in patients with psoriasis |
topic | Investigative Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309860/ https://www.ncbi.nlm.nih.gov/pubmed/32945341 http://dx.doi.org/10.2340/00015555-3638 |
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