Characteristics of Pruritus in Bullous Pemphigoid and Impact on Quality of Life: A Prospective Cohort Study

Pruritus is a common symptom of bullous pemphigoid (BP), but has been poorly studied. The aim of this study was to analyse the characteristics of pruritus in patients with BP and its impact on their quality of life. A multicentre prospective observational study (in 15 French hospitals) was performed...

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Autores principales: BRIAND, Clémence, GOURIER, Greta, POIZEAU, Florence, JELTI, Lamia, BACHELERIE, Marie, QUÉREUX, Gaëlle, JEUDY, Géraldine, ACQUITTER, Marie, INGEN-HOUSZ-ORO, Saskia, CAUX, Frédéric, PROST, Catherine, DARRIGUADE, Anne-Sophie, HERON MERMIN, Diane, MAHÉ, Emmanuel, PICART DAHAN, Catherine, RICHARD, Marie-Aleth, CLERC, Caroline Jade, SALLE DE CHOU, Camille, PLÉE, Julie, ABASQ-THOMAS, Claire, MISERY, Laurent, Brenaut, Emilie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Publication of Acta Dermato-Venereologica 2020
Materias:
Investigative Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309871/
https://www.ncbi.nlm.nih.gov/pubmed/33135772
http://dx.doi.org/10.2340/00015555-3683
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author BRIAND, Clémence
GOURIER, Greta
POIZEAU, Florence
JELTI, Lamia
BACHELERIE, Marie
QUÉREUX, Gaëlle
JEUDY, Géraldine
ACQUITTER, Marie
INGEN-HOUSZ-ORO, Saskia
CAUX, Frédéric
PROST, Catherine
DARRIGUADE, Anne-Sophie
HERON MERMIN, Diane
MAHÉ, Emmanuel
PICART DAHAN, Catherine
RICHARD, Marie-Aleth
CLERC, Caroline Jade
SALLE DE CHOU, Camille
PLÉE, Julie
ABASQ-THOMAS, Claire
MISERY, Laurent
Brenaut, Emilie
author_facet BRIAND, Clémence
GOURIER, Greta
POIZEAU, Florence
JELTI, Lamia
BACHELERIE, Marie
QUÉREUX, Gaëlle
JEUDY, Géraldine
ACQUITTER, Marie
INGEN-HOUSZ-ORO, Saskia
CAUX, Frédéric
PROST, Catherine
DARRIGUADE, Anne-Sophie
HERON MERMIN, Diane
MAHÉ, Emmanuel
PICART DAHAN, Catherine
RICHARD, Marie-Aleth
CLERC, Caroline Jade
SALLE DE CHOU, Camille
PLÉE, Julie
ABASQ-THOMAS, Claire
MISERY, Laurent
Brenaut, Emilie
author_sort BRIAND, Clémence
collection PubMed
description Pruritus is a common symptom of bullous pemphigoid (BP), but has been poorly studied. The aim of this study was to analyse the characteristics of pruritus in patients with BP and its impact on their quality of life. A multicentre prospective observational study (in 15 French hospitals) was performed. A total of 60 patients were included, with a mean age of 77.4 years. Pruritus occurred daily in 85% of patients, with a mean pruritus intensity of 5.2/10. Tingling sensations were present in 72.4% of patients and burning sensations in 68.9%. Pruritus was exacerbated by stress, fatigue and xerosis. The mean ItchyQol score was 56.2/110 and the mean 5-D Itch Scale score was 16.5/25. The severity of pruritus was not related to age, sex, BP activity score, eosinophilia, or anti-BP230 and anti-BP180 autoantibodies. This study revealed that pruritus in BP is poorly tolerated and is an important cause of impaired quality of life.
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spelling pubmed-93098712022-10-20 Characteristics of Pruritus in Bullous Pemphigoid and Impact on Quality of Life: A Prospective Cohort Study BRIAND, Clémence GOURIER, Greta POIZEAU, Florence JELTI, Lamia BACHELERIE, Marie QUÉREUX, Gaëlle JEUDY, Géraldine ACQUITTER, Marie INGEN-HOUSZ-ORO, Saskia CAUX, Frédéric PROST, Catherine DARRIGUADE, Anne-Sophie HERON MERMIN, Diane MAHÉ, Emmanuel PICART DAHAN, Catherine RICHARD, Marie-Aleth CLERC, Caroline Jade SALLE DE CHOU, Camille PLÉE, Julie ABASQ-THOMAS, Claire MISERY, Laurent Brenaut, Emilie Acta Derm Venereol Investigative Report Pruritus is a common symptom of bullous pemphigoid (BP), but has been poorly studied. The aim of this study was to analyse the characteristics of pruritus in patients with BP and its impact on their quality of life. A multicentre prospective observational study (in 15 French hospitals) was performed. A total of 60 patients were included, with a mean age of 77.4 years. Pruritus occurred daily in 85% of patients, with a mean pruritus intensity of 5.2/10. Tingling sensations were present in 72.4% of patients and burning sensations in 68.9%. Pruritus was exacerbated by stress, fatigue and xerosis. The mean ItchyQol score was 56.2/110 and the mean 5-D Itch Scale score was 16.5/25. The severity of pruritus was not related to age, sex, BP activity score, eosinophilia, or anti-BP230 and anti-BP180 autoantibodies. This study revealed that pruritus in BP is poorly tolerated and is an important cause of impaired quality of life. Society for Publication of Acta Dermato-Venereologica 2020-11-12 /pmc/articles/PMC9309871/ /pubmed/33135772 http://dx.doi.org/10.2340/00015555-3683 Text en © 2020 Acta Dermato-Venereologica https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the CC BY-NC license
spellingShingle Investigative Report
BRIAND, Clémence
GOURIER, Greta
POIZEAU, Florence
JELTI, Lamia
BACHELERIE, Marie
QUÉREUX, Gaëlle
JEUDY, Géraldine
ACQUITTER, Marie
INGEN-HOUSZ-ORO, Saskia
CAUX, Frédéric
PROST, Catherine
DARRIGUADE, Anne-Sophie
HERON MERMIN, Diane
MAHÉ, Emmanuel
PICART DAHAN, Catherine
RICHARD, Marie-Aleth
CLERC, Caroline Jade
SALLE DE CHOU, Camille
PLÉE, Julie
ABASQ-THOMAS, Claire
MISERY, Laurent
Brenaut, Emilie
Characteristics of Pruritus in Bullous Pemphigoid and Impact on Quality of Life: A Prospective Cohort Study
title Characteristics of Pruritus in Bullous Pemphigoid and Impact on Quality of Life: A Prospective Cohort Study
title_full Characteristics of Pruritus in Bullous Pemphigoid and Impact on Quality of Life: A Prospective Cohort Study
title_fullStr Characteristics of Pruritus in Bullous Pemphigoid and Impact on Quality of Life: A Prospective Cohort Study
title_full_unstemmed Characteristics of Pruritus in Bullous Pemphigoid and Impact on Quality of Life: A Prospective Cohort Study
title_short Characteristics of Pruritus in Bullous Pemphigoid and Impact on Quality of Life: A Prospective Cohort Study
title_sort characteristics of pruritus in bullous pemphigoid and impact on quality of life: a prospective cohort study
topic Investigative Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309871/
https://www.ncbi.nlm.nih.gov/pubmed/33135772
http://dx.doi.org/10.2340/00015555-3683
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