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Severe acute heart failure during or following cytokine release syndrome after CAR T-cell therapy
Although cardiac dysfunction after chimeric antigen receptor (CAR) T-cell therapy has been increasingly reported, the underlying dynamics and pathogenesis are not well documented. Herein, we describe the clinical presentation and treatment for two patients who developed severe acute heart failure af...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310108/ https://www.ncbi.nlm.nih.gov/pubmed/35898695 http://dx.doi.org/10.1016/j.lrr.2022.100338 |
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author | Yoshihara, Kyoko Orihara, Yoshiyuki Hoshiyama, Tokiko Tamaki, Hiroya Sunayama, Isamu Matsuda, Ikuo Nishikawa, Akinori Kumamoto, Tomoko Samori, Mami Utsunomiya, Nobuto Min, Kyung-Duk Asakura, Masanori Hirota, Seiichi Ishihara, Masaharu Higasa, Satoshi Yoshihara, Satoshi |
author_facet | Yoshihara, Kyoko Orihara, Yoshiyuki Hoshiyama, Tokiko Tamaki, Hiroya Sunayama, Isamu Matsuda, Ikuo Nishikawa, Akinori Kumamoto, Tomoko Samori, Mami Utsunomiya, Nobuto Min, Kyung-Duk Asakura, Masanori Hirota, Seiichi Ishihara, Masaharu Higasa, Satoshi Yoshihara, Satoshi |
author_sort | Yoshihara, Kyoko |
collection | PubMed |
description | Although cardiac dysfunction after chimeric antigen receptor (CAR) T-cell therapy has been increasingly reported, the underlying dynamics and pathogenesis are not well documented. Herein, we describe the clinical presentation and treatment for two patients who developed severe acute heart failure after CAR T-cell therapy. Both cases shared several common characteristics, including the bone marrow involvement at the time of CAR T-cell therapy and early onset of cytokine release syndrome (CRS) with fever developing on the day of CAR T-cell infusion. Patients with early onset and/or severe CRS should be carefully monitored for the possibility of heart failure. |
format | Online Article Text |
id | pubmed-9310108 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-93101082022-07-26 Severe acute heart failure during or following cytokine release syndrome after CAR T-cell therapy Yoshihara, Kyoko Orihara, Yoshiyuki Hoshiyama, Tokiko Tamaki, Hiroya Sunayama, Isamu Matsuda, Ikuo Nishikawa, Akinori Kumamoto, Tomoko Samori, Mami Utsunomiya, Nobuto Min, Kyung-Duk Asakura, Masanori Hirota, Seiichi Ishihara, Masaharu Higasa, Satoshi Yoshihara, Satoshi Leuk Res Rep Case Report Although cardiac dysfunction after chimeric antigen receptor (CAR) T-cell therapy has been increasingly reported, the underlying dynamics and pathogenesis are not well documented. Herein, we describe the clinical presentation and treatment for two patients who developed severe acute heart failure after CAR T-cell therapy. Both cases shared several common characteristics, including the bone marrow involvement at the time of CAR T-cell therapy and early onset of cytokine release syndrome (CRS) with fever developing on the day of CAR T-cell infusion. Patients with early onset and/or severe CRS should be carefully monitored for the possibility of heart failure. Elsevier 2022-07-14 /pmc/articles/PMC9310108/ /pubmed/35898695 http://dx.doi.org/10.1016/j.lrr.2022.100338 Text en © 2022 The Author(s). Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Yoshihara, Kyoko Orihara, Yoshiyuki Hoshiyama, Tokiko Tamaki, Hiroya Sunayama, Isamu Matsuda, Ikuo Nishikawa, Akinori Kumamoto, Tomoko Samori, Mami Utsunomiya, Nobuto Min, Kyung-Duk Asakura, Masanori Hirota, Seiichi Ishihara, Masaharu Higasa, Satoshi Yoshihara, Satoshi Severe acute heart failure during or following cytokine release syndrome after CAR T-cell therapy |
title | Severe acute heart failure during or following cytokine release syndrome after CAR T-cell therapy |
title_full | Severe acute heart failure during or following cytokine release syndrome after CAR T-cell therapy |
title_fullStr | Severe acute heart failure during or following cytokine release syndrome after CAR T-cell therapy |
title_full_unstemmed | Severe acute heart failure during or following cytokine release syndrome after CAR T-cell therapy |
title_short | Severe acute heart failure during or following cytokine release syndrome after CAR T-cell therapy |
title_sort | severe acute heart failure during or following cytokine release syndrome after car t-cell therapy |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310108/ https://www.ncbi.nlm.nih.gov/pubmed/35898695 http://dx.doi.org/10.1016/j.lrr.2022.100338 |
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