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Severe acute heart failure during or following cytokine release syndrome after CAR T-cell therapy

Although cardiac dysfunction after chimeric antigen receptor (CAR) T-cell therapy has been increasingly reported, the underlying dynamics and pathogenesis are not well documented. Herein, we describe the clinical presentation and treatment for two patients who developed severe acute heart failure af...

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Autores principales: Yoshihara, Kyoko, Orihara, Yoshiyuki, Hoshiyama, Tokiko, Tamaki, Hiroya, Sunayama, Isamu, Matsuda, Ikuo, Nishikawa, Akinori, Kumamoto, Tomoko, Samori, Mami, Utsunomiya, Nobuto, Min, Kyung-Duk, Asakura, Masanori, Hirota, Seiichi, Ishihara, Masaharu, Higasa, Satoshi, Yoshihara, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310108/
https://www.ncbi.nlm.nih.gov/pubmed/35898695
http://dx.doi.org/10.1016/j.lrr.2022.100338
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author Yoshihara, Kyoko
Orihara, Yoshiyuki
Hoshiyama, Tokiko
Tamaki, Hiroya
Sunayama, Isamu
Matsuda, Ikuo
Nishikawa, Akinori
Kumamoto, Tomoko
Samori, Mami
Utsunomiya, Nobuto
Min, Kyung-Duk
Asakura, Masanori
Hirota, Seiichi
Ishihara, Masaharu
Higasa, Satoshi
Yoshihara, Satoshi
author_facet Yoshihara, Kyoko
Orihara, Yoshiyuki
Hoshiyama, Tokiko
Tamaki, Hiroya
Sunayama, Isamu
Matsuda, Ikuo
Nishikawa, Akinori
Kumamoto, Tomoko
Samori, Mami
Utsunomiya, Nobuto
Min, Kyung-Duk
Asakura, Masanori
Hirota, Seiichi
Ishihara, Masaharu
Higasa, Satoshi
Yoshihara, Satoshi
author_sort Yoshihara, Kyoko
collection PubMed
description Although cardiac dysfunction after chimeric antigen receptor (CAR) T-cell therapy has been increasingly reported, the underlying dynamics and pathogenesis are not well documented. Herein, we describe the clinical presentation and treatment for two patients who developed severe acute heart failure after CAR T-cell therapy. Both cases shared several common characteristics, including the bone marrow involvement at the time of CAR T-cell therapy and early onset of cytokine release syndrome (CRS) with fever developing on the day of CAR T-cell infusion. Patients with early onset and/or severe CRS should be carefully monitored for the possibility of heart failure.
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spelling pubmed-93101082022-07-26 Severe acute heart failure during or following cytokine release syndrome after CAR T-cell therapy Yoshihara, Kyoko Orihara, Yoshiyuki Hoshiyama, Tokiko Tamaki, Hiroya Sunayama, Isamu Matsuda, Ikuo Nishikawa, Akinori Kumamoto, Tomoko Samori, Mami Utsunomiya, Nobuto Min, Kyung-Duk Asakura, Masanori Hirota, Seiichi Ishihara, Masaharu Higasa, Satoshi Yoshihara, Satoshi Leuk Res Rep Case Report Although cardiac dysfunction after chimeric antigen receptor (CAR) T-cell therapy has been increasingly reported, the underlying dynamics and pathogenesis are not well documented. Herein, we describe the clinical presentation and treatment for two patients who developed severe acute heart failure after CAR T-cell therapy. Both cases shared several common characteristics, including the bone marrow involvement at the time of CAR T-cell therapy and early onset of cytokine release syndrome (CRS) with fever developing on the day of CAR T-cell infusion. Patients with early onset and/or severe CRS should be carefully monitored for the possibility of heart failure. Elsevier 2022-07-14 /pmc/articles/PMC9310108/ /pubmed/35898695 http://dx.doi.org/10.1016/j.lrr.2022.100338 Text en © 2022 The Author(s). Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Yoshihara, Kyoko
Orihara, Yoshiyuki
Hoshiyama, Tokiko
Tamaki, Hiroya
Sunayama, Isamu
Matsuda, Ikuo
Nishikawa, Akinori
Kumamoto, Tomoko
Samori, Mami
Utsunomiya, Nobuto
Min, Kyung-Duk
Asakura, Masanori
Hirota, Seiichi
Ishihara, Masaharu
Higasa, Satoshi
Yoshihara, Satoshi
Severe acute heart failure during or following cytokine release syndrome after CAR T-cell therapy
title Severe acute heart failure during or following cytokine release syndrome after CAR T-cell therapy
title_full Severe acute heart failure during or following cytokine release syndrome after CAR T-cell therapy
title_fullStr Severe acute heart failure during or following cytokine release syndrome after CAR T-cell therapy
title_full_unstemmed Severe acute heart failure during or following cytokine release syndrome after CAR T-cell therapy
title_short Severe acute heart failure during or following cytokine release syndrome after CAR T-cell therapy
title_sort severe acute heart failure during or following cytokine release syndrome after car t-cell therapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310108/
https://www.ncbi.nlm.nih.gov/pubmed/35898695
http://dx.doi.org/10.1016/j.lrr.2022.100338
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