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High visit‐to‐visit blood pressure variability predicts global cognitive decline: The Multi‐Ethnic Study of Atherosclerosis
BACKGROUND: Research of hypertension‐related risk factors for Alzheimer's disease has typically focused on blood pressure (BP) levels, despite evidence that high blood pressure variability (BPV) over time may predict poorer cardiovascular, neuropathological, and neurocognitive outcomes. We eval...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310191/ https://www.ncbi.nlm.nih.gov/pubmed/35898668 http://dx.doi.org/10.1002/trc2.12342 |
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author | Daniel, George D. Chen, Haiying Bertoni, Alain G. Hughes, Timothy M. Hayden, Kathleen M. |
author_facet | Daniel, George D. Chen, Haiying Bertoni, Alain G. Hughes, Timothy M. Hayden, Kathleen M. |
author_sort | Daniel, George D. |
collection | PubMed |
description | BACKGROUND: Research of hypertension‐related risk factors for Alzheimer's disease has typically focused on blood pressure (BP) levels, despite evidence that high blood pressure variability (BPV) over time may predict poorer cardiovascular, neuropathological, and neurocognitive outcomes. We evaluated associations between BPV and cognitive function in the Multi‐Ethnic Study of Atherosclerosis (MESA). METHODS: Multivariable linear and logistic regression analyses of BP data across six examinations were used to determine associations that BPV (average real variability [ARV], variability independent of the mean [VIM]) and group‐based latent BP trajectories have with cognitive function, decline, and impairment, measured by the Cognitive Abilities Screening Instrument (CASI), Digit Symbol Coding (DSC), and Digit Span tests. RESULTS: Participants (N = 1314; mean baseline age = 57) were 50% female, and 48% White. Higher systolic (β = −0.06, 95% confidence interval [CI]: −0.12, −0.0001) and diastolic (β = −0.08, 95% CI: −0.14, −0.02) ARV predicted increased global cognitive decline after covariate adjustment. Stronger relationships between BPV and global cognition were in older, White and Black participants, apolipoprotein E (APOE) ε4 non‐carriers, male participants, and non‐antihypertensive medication users. CONCLUSION: Results suggest that higher systolic and diastolic BPV is an independent risk factor for cognitive dysfunction and decline in this multi‐ethnic cohort. This relationship differs across demographic and clinical characteristics. |
format | Online Article Text |
id | pubmed-9310191 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93101912022-07-26 High visit‐to‐visit blood pressure variability predicts global cognitive decline: The Multi‐Ethnic Study of Atherosclerosis Daniel, George D. Chen, Haiying Bertoni, Alain G. Hughes, Timothy M. Hayden, Kathleen M. Alzheimers Dement (N Y) Research Articles BACKGROUND: Research of hypertension‐related risk factors for Alzheimer's disease has typically focused on blood pressure (BP) levels, despite evidence that high blood pressure variability (BPV) over time may predict poorer cardiovascular, neuropathological, and neurocognitive outcomes. We evaluated associations between BPV and cognitive function in the Multi‐Ethnic Study of Atherosclerosis (MESA). METHODS: Multivariable linear and logistic regression analyses of BP data across six examinations were used to determine associations that BPV (average real variability [ARV], variability independent of the mean [VIM]) and group‐based latent BP trajectories have with cognitive function, decline, and impairment, measured by the Cognitive Abilities Screening Instrument (CASI), Digit Symbol Coding (DSC), and Digit Span tests. RESULTS: Participants (N = 1314; mean baseline age = 57) were 50% female, and 48% White. Higher systolic (β = −0.06, 95% confidence interval [CI]: −0.12, −0.0001) and diastolic (β = −0.08, 95% CI: −0.14, −0.02) ARV predicted increased global cognitive decline after covariate adjustment. Stronger relationships between BPV and global cognition were in older, White and Black participants, apolipoprotein E (APOE) ε4 non‐carriers, male participants, and non‐antihypertensive medication users. CONCLUSION: Results suggest that higher systolic and diastolic BPV is an independent risk factor for cognitive dysfunction and decline in this multi‐ethnic cohort. This relationship differs across demographic and clinical characteristics. John Wiley and Sons Inc. 2022-07-25 /pmc/articles/PMC9310191/ /pubmed/35898668 http://dx.doi.org/10.1002/trc2.12342 Text en © 2022 The Authors. Alzheimer's & Dementia: Translational Research & Clinical Interventions published by Wiley Periodicals LLC on behalf of Alzheimer's Association. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Research Articles Daniel, George D. Chen, Haiying Bertoni, Alain G. Hughes, Timothy M. Hayden, Kathleen M. High visit‐to‐visit blood pressure variability predicts global cognitive decline: The Multi‐Ethnic Study of Atherosclerosis |
title | High visit‐to‐visit blood pressure variability predicts global cognitive decline: The Multi‐Ethnic Study of Atherosclerosis |
title_full | High visit‐to‐visit blood pressure variability predicts global cognitive decline: The Multi‐Ethnic Study of Atherosclerosis |
title_fullStr | High visit‐to‐visit blood pressure variability predicts global cognitive decline: The Multi‐Ethnic Study of Atherosclerosis |
title_full_unstemmed | High visit‐to‐visit blood pressure variability predicts global cognitive decline: The Multi‐Ethnic Study of Atherosclerosis |
title_short | High visit‐to‐visit blood pressure variability predicts global cognitive decline: The Multi‐Ethnic Study of Atherosclerosis |
title_sort | high visit‐to‐visit blood pressure variability predicts global cognitive decline: the multi‐ethnic study of atherosclerosis |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310191/ https://www.ncbi.nlm.nih.gov/pubmed/35898668 http://dx.doi.org/10.1002/trc2.12342 |
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