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The role of chemotherapy in the treatment of advanced appendiceal cancers: summary of the literature and future directions

Appendiceal cancer is rare and encompasses a diverse group of tumours ranging from low-grade appendiceal mucinous neoplasms to high-grade adenocarcinomas. Appendiceal cancers often spread to the peritoneal cavity causing extensive mucinous dissemination and peritoneal metastases. Prognosis varies wi...

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Autores principales: Strach, Madeleine C., Sutherland, Sarah, Horvath, Lisa G., Mahon, Kate
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310237/
https://www.ncbi.nlm.nih.gov/pubmed/35898968
http://dx.doi.org/10.1177/17588359221112478
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author Strach, Madeleine C.
Sutherland, Sarah
Horvath, Lisa G.
Mahon, Kate
author_facet Strach, Madeleine C.
Sutherland, Sarah
Horvath, Lisa G.
Mahon, Kate
author_sort Strach, Madeleine C.
collection PubMed
description Appendiceal cancer is rare and encompasses a diverse group of tumours ranging from low-grade appendiceal mucinous neoplasms to high-grade adenocarcinomas. Appendiceal cancers often spread to the peritoneal cavity causing extensive mucinous dissemination and peritoneal metastases. Prognosis varies with histological subtype. Cytoreductive surgery and heated intraperitoneal chemotherapy is well-established as the most effective treatment achieving long-term survival in some patients. Chemotherapy regimens used to treat appendiceal cancer are extrapolated from the colorectal cancer setting, but disease biology differs and outcomes are inferior. The role of chemotherapy in the treatment of appendiceal cancer remains poorly defined. There is an urgent need to develop novel tailored treatment strategies in the perioperative and unresectable setting. This review aims to evaluate the literature for patients who received intraperitoneal and systemic chemotherapy for appendiceal cancers.
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spelling pubmed-93102372022-07-26 The role of chemotherapy in the treatment of advanced appendiceal cancers: summary of the literature and future directions Strach, Madeleine C. Sutherland, Sarah Horvath, Lisa G. Mahon, Kate Ther Adv Med Oncol Review Appendiceal cancer is rare and encompasses a diverse group of tumours ranging from low-grade appendiceal mucinous neoplasms to high-grade adenocarcinomas. Appendiceal cancers often spread to the peritoneal cavity causing extensive mucinous dissemination and peritoneal metastases. Prognosis varies with histological subtype. Cytoreductive surgery and heated intraperitoneal chemotherapy is well-established as the most effective treatment achieving long-term survival in some patients. Chemotherapy regimens used to treat appendiceal cancer are extrapolated from the colorectal cancer setting, but disease biology differs and outcomes are inferior. The role of chemotherapy in the treatment of appendiceal cancer remains poorly defined. There is an urgent need to develop novel tailored treatment strategies in the perioperative and unresectable setting. This review aims to evaluate the literature for patients who received intraperitoneal and systemic chemotherapy for appendiceal cancers. SAGE Publications 2022-07-23 /pmc/articles/PMC9310237/ /pubmed/35898968 http://dx.doi.org/10.1177/17588359221112478 Text en © The Author(s), 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Strach, Madeleine C.
Sutherland, Sarah
Horvath, Lisa G.
Mahon, Kate
The role of chemotherapy in the treatment of advanced appendiceal cancers: summary of the literature and future directions
title The role of chemotherapy in the treatment of advanced appendiceal cancers: summary of the literature and future directions
title_full The role of chemotherapy in the treatment of advanced appendiceal cancers: summary of the literature and future directions
title_fullStr The role of chemotherapy in the treatment of advanced appendiceal cancers: summary of the literature and future directions
title_full_unstemmed The role of chemotherapy in the treatment of advanced appendiceal cancers: summary of the literature and future directions
title_short The role of chemotherapy in the treatment of advanced appendiceal cancers: summary of the literature and future directions
title_sort role of chemotherapy in the treatment of advanced appendiceal cancers: summary of the literature and future directions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310237/
https://www.ncbi.nlm.nih.gov/pubmed/35898968
http://dx.doi.org/10.1177/17588359221112478
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