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The role of chemotherapy in the treatment of advanced appendiceal cancers: summary of the literature and future directions
Appendiceal cancer is rare and encompasses a diverse group of tumours ranging from low-grade appendiceal mucinous neoplasms to high-grade adenocarcinomas. Appendiceal cancers often spread to the peritoneal cavity causing extensive mucinous dissemination and peritoneal metastases. Prognosis varies wi...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310237/ https://www.ncbi.nlm.nih.gov/pubmed/35898968 http://dx.doi.org/10.1177/17588359221112478 |
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author | Strach, Madeleine C. Sutherland, Sarah Horvath, Lisa G. Mahon, Kate |
author_facet | Strach, Madeleine C. Sutherland, Sarah Horvath, Lisa G. Mahon, Kate |
author_sort | Strach, Madeleine C. |
collection | PubMed |
description | Appendiceal cancer is rare and encompasses a diverse group of tumours ranging from low-grade appendiceal mucinous neoplasms to high-grade adenocarcinomas. Appendiceal cancers often spread to the peritoneal cavity causing extensive mucinous dissemination and peritoneal metastases. Prognosis varies with histological subtype. Cytoreductive surgery and heated intraperitoneal chemotherapy is well-established as the most effective treatment achieving long-term survival in some patients. Chemotherapy regimens used to treat appendiceal cancer are extrapolated from the colorectal cancer setting, but disease biology differs and outcomes are inferior. The role of chemotherapy in the treatment of appendiceal cancer remains poorly defined. There is an urgent need to develop novel tailored treatment strategies in the perioperative and unresectable setting. This review aims to evaluate the literature for patients who received intraperitoneal and systemic chemotherapy for appendiceal cancers. |
format | Online Article Text |
id | pubmed-9310237 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-93102372022-07-26 The role of chemotherapy in the treatment of advanced appendiceal cancers: summary of the literature and future directions Strach, Madeleine C. Sutherland, Sarah Horvath, Lisa G. Mahon, Kate Ther Adv Med Oncol Review Appendiceal cancer is rare and encompasses a diverse group of tumours ranging from low-grade appendiceal mucinous neoplasms to high-grade adenocarcinomas. Appendiceal cancers often spread to the peritoneal cavity causing extensive mucinous dissemination and peritoneal metastases. Prognosis varies with histological subtype. Cytoreductive surgery and heated intraperitoneal chemotherapy is well-established as the most effective treatment achieving long-term survival in some patients. Chemotherapy regimens used to treat appendiceal cancer are extrapolated from the colorectal cancer setting, but disease biology differs and outcomes are inferior. The role of chemotherapy in the treatment of appendiceal cancer remains poorly defined. There is an urgent need to develop novel tailored treatment strategies in the perioperative and unresectable setting. This review aims to evaluate the literature for patients who received intraperitoneal and systemic chemotherapy for appendiceal cancers. SAGE Publications 2022-07-23 /pmc/articles/PMC9310237/ /pubmed/35898968 http://dx.doi.org/10.1177/17588359221112478 Text en © The Author(s), 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Review Strach, Madeleine C. Sutherland, Sarah Horvath, Lisa G. Mahon, Kate The role of chemotherapy in the treatment of advanced appendiceal cancers: summary of the literature and future directions |
title | The role of chemotherapy in the treatment of advanced appendiceal cancers: summary of the literature and future directions |
title_full | The role of chemotherapy in the treatment of advanced appendiceal cancers: summary of the literature and future directions |
title_fullStr | The role of chemotherapy in the treatment of advanced appendiceal cancers: summary of the literature and future directions |
title_full_unstemmed | The role of chemotherapy in the treatment of advanced appendiceal cancers: summary of the literature and future directions |
title_short | The role of chemotherapy in the treatment of advanced appendiceal cancers: summary of the literature and future directions |
title_sort | role of chemotherapy in the treatment of advanced appendiceal cancers: summary of the literature and future directions |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310237/ https://www.ncbi.nlm.nih.gov/pubmed/35898968 http://dx.doi.org/10.1177/17588359221112478 |
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