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COVID-19 causes neuronal degeneration and reduces neurogenesis in human hippocampus
Recent investigations of COVID-19 have largely focused on the effects of this novel virus on the vital organs in order to efficiently assist individuals who have recovered from the disease. In the present study we used hippocampal tissue samples extracted from people who died after COVID-19. Utilizi...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310365/ https://www.ncbi.nlm.nih.gov/pubmed/35876935 http://dx.doi.org/10.1007/s10495-022-01754-9 |
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author | Bayat, Amir-Hossein Azimi, Helia Hassani Moghaddam, Meysam Ebrahimi, Vahid Fathi, Mobina Vakili, Kimia Mahmoudiasl, Gholam-Reza Forouzesh, Mahdi Boroujeni, Mahdi Eskandarian Nariman, Zahra Abbaszadeh, Hojjat-Allah Aryan, Arefeh Aliaghaei, Abbas Abdollahifar, Mohammad-Amin |
author_facet | Bayat, Amir-Hossein Azimi, Helia Hassani Moghaddam, Meysam Ebrahimi, Vahid Fathi, Mobina Vakili, Kimia Mahmoudiasl, Gholam-Reza Forouzesh, Mahdi Boroujeni, Mahdi Eskandarian Nariman, Zahra Abbaszadeh, Hojjat-Allah Aryan, Arefeh Aliaghaei, Abbas Abdollahifar, Mohammad-Amin |
author_sort | Bayat, Amir-Hossein |
collection | PubMed |
description | Recent investigations of COVID-19 have largely focused on the effects of this novel virus on the vital organs in order to efficiently assist individuals who have recovered from the disease. In the present study we used hippocampal tissue samples extracted from people who died after COVID-19. Utilizing histological techniques to analyze glial and neuronal cells we illuminated a massive degeneration of neuronal cells and changes in glial cells morphology in hippocampal samples. The results showed that in hippocampus of the studied brains there were morphological changes in pyramidal cells, an increase in apoptosis, a drop in neurogenesis, and change in spatial distribution of neurons in the pyramidal and granular layer. It was also demonstrated that COVID-19 alter the morphological characteristics and distribution of astrocyte and microglia cells. While the exact mechanism(s) by which the virus causes neuronal loss and morphology in the central nervous system (CNS) remains to be determined, it is necessary to monitor the effect of SARS-CoV-2 infection on CNS compartments like the hippocampus in future investigations. As a result of what happened in the hippocampus secondary to COVID-19, memory impairment may be a long-term neurological complication which can be a predisposing factor for neurodegenerative disorders through neuroinflammation and oxidative stress mechanisms. |
format | Online Article Text |
id | pubmed-9310365 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-93103652022-07-25 COVID-19 causes neuronal degeneration and reduces neurogenesis in human hippocampus Bayat, Amir-Hossein Azimi, Helia Hassani Moghaddam, Meysam Ebrahimi, Vahid Fathi, Mobina Vakili, Kimia Mahmoudiasl, Gholam-Reza Forouzesh, Mahdi Boroujeni, Mahdi Eskandarian Nariman, Zahra Abbaszadeh, Hojjat-Allah Aryan, Arefeh Aliaghaei, Abbas Abdollahifar, Mohammad-Amin Apoptosis Article Recent investigations of COVID-19 have largely focused on the effects of this novel virus on the vital organs in order to efficiently assist individuals who have recovered from the disease. In the present study we used hippocampal tissue samples extracted from people who died after COVID-19. Utilizing histological techniques to analyze glial and neuronal cells we illuminated a massive degeneration of neuronal cells and changes in glial cells morphology in hippocampal samples. The results showed that in hippocampus of the studied brains there were morphological changes in pyramidal cells, an increase in apoptosis, a drop in neurogenesis, and change in spatial distribution of neurons in the pyramidal and granular layer. It was also demonstrated that COVID-19 alter the morphological characteristics and distribution of astrocyte and microglia cells. While the exact mechanism(s) by which the virus causes neuronal loss and morphology in the central nervous system (CNS) remains to be determined, it is necessary to monitor the effect of SARS-CoV-2 infection on CNS compartments like the hippocampus in future investigations. As a result of what happened in the hippocampus secondary to COVID-19, memory impairment may be a long-term neurological complication which can be a predisposing factor for neurodegenerative disorders through neuroinflammation and oxidative stress mechanisms. Springer US 2022-07-25 2022 /pmc/articles/PMC9310365/ /pubmed/35876935 http://dx.doi.org/10.1007/s10495-022-01754-9 Text en © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Article Bayat, Amir-Hossein Azimi, Helia Hassani Moghaddam, Meysam Ebrahimi, Vahid Fathi, Mobina Vakili, Kimia Mahmoudiasl, Gholam-Reza Forouzesh, Mahdi Boroujeni, Mahdi Eskandarian Nariman, Zahra Abbaszadeh, Hojjat-Allah Aryan, Arefeh Aliaghaei, Abbas Abdollahifar, Mohammad-Amin COVID-19 causes neuronal degeneration and reduces neurogenesis in human hippocampus |
title | COVID-19 causes neuronal degeneration and reduces neurogenesis in human hippocampus |
title_full | COVID-19 causes neuronal degeneration and reduces neurogenesis in human hippocampus |
title_fullStr | COVID-19 causes neuronal degeneration and reduces neurogenesis in human hippocampus |
title_full_unstemmed | COVID-19 causes neuronal degeneration and reduces neurogenesis in human hippocampus |
title_short | COVID-19 causes neuronal degeneration and reduces neurogenesis in human hippocampus |
title_sort | covid-19 causes neuronal degeneration and reduces neurogenesis in human hippocampus |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310365/ https://www.ncbi.nlm.nih.gov/pubmed/35876935 http://dx.doi.org/10.1007/s10495-022-01754-9 |
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