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Surgical outcomes associated with sleep apnea syndrome in Stanford A aortic dissection patients
BACKGROUND: Patients suffering from aortic dissection (AD) often experience sleep apnea syndrome (SAS), which aggravates their respiratory function and aortic false lumen expansion. METHODS: We analyzed the peri-operative data of Stanford A AD patients, with or without SAS, between January 2017 and...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310499/ https://www.ncbi.nlm.nih.gov/pubmed/35871643 http://dx.doi.org/10.1186/s12872-022-02775-7 |
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author | Luo, Zeng-Rong Yu, Ling-Li Chen, Liang-Wan |
author_facet | Luo, Zeng-Rong Yu, Ling-Li Chen, Liang-Wan |
author_sort | Luo, Zeng-Rong |
collection | PubMed |
description | BACKGROUND: Patients suffering from aortic dissection (AD) often experience sleep apnea syndrome (SAS), which aggravates their respiratory function and aortic false lumen expansion. METHODS: We analyzed the peri-operative data of Stanford A AD patients, with or without SAS, between January 2017 and June 2019. Subjects were separated into SAS positive (SAS(+)) and SAS negative (SAS(−)) cohorts, based on the Apnea-Hypopnea Index (AHI) and the Oxygen Desaturation Index (ODI). We next analyzed variables between the SAS(+) and SAS(−) groups. RESULTS: 155, out of 198 AAD patients, were enlisted for this study. SAS(+) patients exhibited higher rates of pneumonia (p < 0.001), heart failure (HF, p = 0.038), acute kidney injury (AKI, p = 0.001), ventilation time (p = 0.009), and hospitalization duration (p < 0.001). According to subsequent follow-ups, the unstented aorta false lumen dilatation (FLD) rate increased markedly, with increasing degree of SAS (p < 0.001, according to AHI and ODI). The SAS(+) patients exhibited worse cumulative survival rate (p = 0.025). The significant risk factors (RF) for poor survival were: severe (p = 0.002) or moderate SAS (p = 0.008), prolonged ventilation time (p = 0.018), AKI (p = 0.015), HF New York Heart Association (NYHA) IV (p = 0.005) or III (p = 0.015), pneumonia (p = 0.005), Marfan syndrome (p = 0.010), systolic blood pressure (BP) upon arrival (p = 0.009), and BMI ≥ 30 (p = 0.004). CONCLUSIONS: SAS(+) Stanford A AD patients primarily exhibited higher rates of complications and low survival rates in the mid-time follow-up. Hence, the RFs associated with poor survival must be monitored carefully in SAS patients. Moreover, the FLD rate is related to the degree of SAS, thus treating SAS may mitigate FLD. |
format | Online Article Text |
id | pubmed-9310499 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-93104992022-07-26 Surgical outcomes associated with sleep apnea syndrome in Stanford A aortic dissection patients Luo, Zeng-Rong Yu, Ling-Li Chen, Liang-Wan BMC Cardiovasc Disord Research BACKGROUND: Patients suffering from aortic dissection (AD) often experience sleep apnea syndrome (SAS), which aggravates their respiratory function and aortic false lumen expansion. METHODS: We analyzed the peri-operative data of Stanford A AD patients, with or without SAS, between January 2017 and June 2019. Subjects were separated into SAS positive (SAS(+)) and SAS negative (SAS(−)) cohorts, based on the Apnea-Hypopnea Index (AHI) and the Oxygen Desaturation Index (ODI). We next analyzed variables between the SAS(+) and SAS(−) groups. RESULTS: 155, out of 198 AAD patients, were enlisted for this study. SAS(+) patients exhibited higher rates of pneumonia (p < 0.001), heart failure (HF, p = 0.038), acute kidney injury (AKI, p = 0.001), ventilation time (p = 0.009), and hospitalization duration (p < 0.001). According to subsequent follow-ups, the unstented aorta false lumen dilatation (FLD) rate increased markedly, with increasing degree of SAS (p < 0.001, according to AHI and ODI). The SAS(+) patients exhibited worse cumulative survival rate (p = 0.025). The significant risk factors (RF) for poor survival were: severe (p = 0.002) or moderate SAS (p = 0.008), prolonged ventilation time (p = 0.018), AKI (p = 0.015), HF New York Heart Association (NYHA) IV (p = 0.005) or III (p = 0.015), pneumonia (p = 0.005), Marfan syndrome (p = 0.010), systolic blood pressure (BP) upon arrival (p = 0.009), and BMI ≥ 30 (p = 0.004). CONCLUSIONS: SAS(+) Stanford A AD patients primarily exhibited higher rates of complications and low survival rates in the mid-time follow-up. Hence, the RFs associated with poor survival must be monitored carefully in SAS patients. Moreover, the FLD rate is related to the degree of SAS, thus treating SAS may mitigate FLD. BioMed Central 2022-07-24 /pmc/articles/PMC9310499/ /pubmed/35871643 http://dx.doi.org/10.1186/s12872-022-02775-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Luo, Zeng-Rong Yu, Ling-Li Chen, Liang-Wan Surgical outcomes associated with sleep apnea syndrome in Stanford A aortic dissection patients |
title | Surgical outcomes associated with sleep apnea syndrome in Stanford A aortic dissection patients |
title_full | Surgical outcomes associated with sleep apnea syndrome in Stanford A aortic dissection patients |
title_fullStr | Surgical outcomes associated with sleep apnea syndrome in Stanford A aortic dissection patients |
title_full_unstemmed | Surgical outcomes associated with sleep apnea syndrome in Stanford A aortic dissection patients |
title_short | Surgical outcomes associated with sleep apnea syndrome in Stanford A aortic dissection patients |
title_sort | surgical outcomes associated with sleep apnea syndrome in stanford a aortic dissection patients |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310499/ https://www.ncbi.nlm.nih.gov/pubmed/35871643 http://dx.doi.org/10.1186/s12872-022-02775-7 |
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