Small-molecule inhibitor of intestinal anion exchanger SLC26A3 for treatment of hyperoxaluria and nephrolithiasis

Nephrolithiasis is a common and recurrent disease affecting 9% of the US population. Hyperoxaluria is major risk factor for calcium oxalate kidney stones, which constitute two-thirds of all kidney stones. SLC26A3 (DRA, downregulated in adenoma) is an anion exchanger of chloride, bicarbonate, and oxa...

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Detalles Bibliográficos
Autores principales: Cil, Onur, Chu, Tifany, Lee, Sujin, Haggie, Peter M., Verkman, Alan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310519/
https://www.ncbi.nlm.nih.gov/pubmed/35608921
http://dx.doi.org/10.1172/jci.insight.153359

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310519/
https://www.ncbi.nlm.nih.gov/pubmed/35608921
http://dx.doi.org/10.1172/jci.insight.153359

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