MEF2C opposes Notch in lymphoid lineage decision and drives leukemia in the thymus

Rearrangements that drive ectopic MEF2C expression have recurrently been found in patients with human early thymocyte progenitor acute lymphoblastic leukemia (ETP-ALL). Here, we show high levels of MEF2C expression in patients with ETP-ALL. Using both in vivo and in vitro models of ETP-ALL, we demon...

Descripción completa

Detalles Bibliográficos
Autores principales: Canté-Barrett, Kirsten, Meijer, Mariska T., Cordo’, Valentina, Hagelaar, Rico, Yang, Wentao, Yu, Jiyang, Smits, Willem K., Nulle, Marloes E., Jansen, Joris P., Pieters, Rob, Yang, Jun J., Haigh, Jody J., Goossens, Steven, Meijerink, Jules P.P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310523/
https://www.ncbi.nlm.nih.gov/pubmed/35536646
http://dx.doi.org/10.1172/jci.insight.150363

Ejemplares similares

Ejemplares similares